This important reference provides up-to-date information on all aspects of ribosome-inactivating proteins (RIPs). Including a list of all known RIPs, their distribution in nature, structure, genetics and chemical and immunological properties, this reference covers mechanisms of action, including the enzymatic activity on various polynucleotide substrates; the interaction with, and entry into cells; the toxicity to animals, including the pathology of poisoning; and the immunomodulatory and allergenic activity. The book further emphasizes the use of immunotoxins and other conjugates in clinical trials for the therapy of cancer and intractable pain.
Table des matières
Contributors vii
Preface xi
1 Introduction and History 1
Fiorenzo Stirpe
2 Occurrence and Taxonomical Distribution of
Ribosome-inactivating Proteins Belonging to the Ricin/Shiga Toxin
Superfamily 11
Chenjing Shang, Willy J. Peumans, and Els J. M. Van
Damme
3 Ribosome-inactivating Proteins from Phytolaccaceae 28
Augusto Parente, Angela Chambery, Antimo Di Maro, Rosita Russo,
and Valeria Severino
4 Ribosome-inactivating Proteins in Caryophyllaceae,
Cucurbitaceae, and Euphorbiaceae 44
Tzi Bun Ng and Jack Ho Wong
5 Non-toxic Type 2 Ribosome-inactivating Proteins 67
Pilar Jiménez, Manuel José Gayoso, and Tomás
Girbés
6 The Intracellular Journey of Type 2 Ribosome-inactivating
Proteins 83
Robert A. Spooner and J. Michael Lord
7 Shiga Toxins: The Ribosome-inactivating Proteins from
Pathogenic Bacteria 97
Maurizio Brigotti
8 The Structure and Action of Ribosome-inactivating Proteins
111
Jon D. Robertus and Arthur F. Monzingo
9 Updated Model of the Molecular Evolution of RIP Genes
134
Willy J Peumans, Chenjing Shang, and Els J. M. Van Damme
10 Enzymology of the Ribosome-inactivating Proteins 151
Yaeta Endo
11 A Long Journey to the Cytosol: What do We Know about Entry of
Type 1 RIPs Inside a Mammalian Cell? 161
Rodolfo Ippoliti and Maria Serena Fabbrini
12 Ribosome-inactivating Proteins: Pathology from Cells to
Organs 178
Gareth D. Griffiths
13 Antiviral and Antifungal Properties of RIPs 198
Gabriela Krivdova, Kira C. M. Neller, Bijal A. Parikh, and
Katalin A. Hudak
14 Insecticidal and Antifungal Activities of
Ribosome-inactivating Proteins 212
Lúcia Rosane Bertholdo Vargas and Célia Regina
Carlini
15 Immunology of RIPs and their Immunotoxins 223
Giulio Fracasso and Marco Colombatti
16 Ribosome-inactivating Proteins in Cancer Treatment 244
Douglas A. Lappi and Fiorenzo Stirpe
17 Nervous System Research with RIP Conjugates: From
Determination of Function to Therapy 253
Douglas A. Lappi, Jack Feldman, Dale Sengelaub, and Jill
Mc Gaughy
18 Embryotoxic and Abortifacient Activities of
Ribosome-inactivating Proteins 270
Wood Yee Chan, Jack Ho Wong, and Tzi Bun Ng
19 The Potential for Misuse of Ribosome-inactivating Proteins
281
Gareth D. Griffiths
Index 287
Color plates appear between pages 116 and 117
A propos de l’auteur
Fiorenzo Stirpe is Professor Emeritus at the Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Italy.
Douglas A. Lappi is the President and Chief Scientific Officer of Advanced Targeting Systems, USA.
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