Biocatalysis is rapidly evolving into a key technology for the
discovery and production of chemicals, especially in the
pharmaceutical industry, where high yielding chemo-, regio-, and
enantioselective reactions are critical. Taking the latest
breakthroughs in genomics and proteomics into consideration,
Biocatalysis for the Pharmaceutical Industry concisely yet
comprehensively discusses the modern application of biocatalysis to
drug discovery, development, and manufacturing. Written by a team
of leading experts, the book offers deep insight into this cutting
edge field.
* Covers a wide range of topics in a systematic manner with an
emphasis on industrial applications
* Provides a thorough introduction to the latest biocatalysts,
modern expression hosts, state-of-the-art directed evolution, high
throughput screening, and bioprocess engineering
* Addresses frontier subjects such as emerging enzymes,
metabolite profiling, combinatorial biosynthesis, metabolic
engineering, and autonomous enzymes for the synthesis and
development of chiral molecules, drug metabolites, and
semi-synthetic medicinal compounds and natural product analogs
* Highlights the impact of biocatalysis on green chemistry
* Contains numerous graphics to illustrate concepts and
techniques
Biocatalysis for the Pharmaceutical Industry is an
essential resource for scientists, engineers, and R&D policy
makers in the fine chemical, pharmaceutical, and biotech
industries. It is also an invaluable tool for academic researchers
and advanced students of organic and materials synthesis, chemical
biology, and medicinal chemistry.
Table of Content
1. Enzymes and Their Synthetic Applications: An Overview
2. Expression hosts for enzyme discovery and production
3. Directed Enzyme Evolution and High Throughput Screening
4. Applications of reaction engineering to industrial biotransformations
5. Chiral synthesis of pharmaceutical intermediates using oxynitrilases
6. Expanding the Scope of Aldolases as Tools for Organic Synthesis
7. Synthetic Applications of Ketoreductases and Alcohol Oxidases
8. Applications of Nitrile Hydratases and Nitrilases
9. Biosynthesis of drug metabolites
10. Application of Whole Cell Biotransformation in Pharmaceutical Industry
11. Combinatorial Biosynthesis of Pharmaceutical Natural Products
12. Metabolic engineering for the development and manufacturing of pharmaceuticals
13. Multimodular Synthases and Supporting Enzymes for Chemical Production
14. Green Chemistry with Biocatalysis for Production of Pharmaceuticals
About the author
Dr. Junhua Tao is co-founder and Chief Scientific Officer at
Bio Verdant, Inc.USA. He was the Head of the Biotransformation Group
at Pfizer Global R&D from 2000 to 2005. Trained in synthetic
organic chemistry, Dr. Tao has published over 50 papers and serve
as an advisory board member of Engineering in Life Sciences
Prof. Guo-Qiang Lin is a professor at Shanghai Institute
of Organic Chemistry, the Chinese Academy of Sciences, China. With
over 150 publications, Prof. Lin is well recognized in synthetic
organic chemistry and medicinal chemistry. He is associate editors
for three journals in the fields and an Executive Board Member for
Tetrahedron.
Prof. Andreas Liese is Professor of Technical
Biochemistry and Head of Institute of Technical Biocatalysis,
Hamburg University of Technology, Germany. Worked in both academia
and pharmaceutical industry, Prof. Liese has made significant
contributions to industrial biotransformations, enzyme technology
and biochemical engineering. He is a member of the editorial board,
Journal of Molecular Catalysis B and has published over 50 papers
and 2 books.
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