The definitive compendium of bioassay procedures and applications
A virtual encyclopedia of key bioassay protocols, this up-to-date, essential resource reviews the methods and applications of bioassays that quantify drug activity and evaluate the validity of pharmacological models.
Demonstrating the specific ways in which various pharmaceutical bioassays interpret the activity of drug molecules, the book covers the evaluation and screening of drug compounds in a wide spectrum of therapeutic categories.
Throughout, the authors use various models to link experimental observations with findings that clarify the effect of drug compounds on cellular biology and measure the pharmacological activity of chemical substances. This provides an important technological platform for successful drug research and clinical therapy, making Pharmaceutical Bioassays an ideal sourcebook for pharmacologists, pharmaceutical and medical researchers, analytical chemists, toxicologists, and students.
Just as a fundamental knowledge of pharmaceutical bioassays is vital to understanding how bioactive agents and new drugs are defined, discovered, and developed, so too is this indispensable reference, which:
* Offers a complete reference on pharmaceutical bioassays and their specific applications in the assessment of therapies for cancer, Alzheimer’s, diabetes, epilepsy, inflammation, antimalarials, pharmacogenomics, and other major therapeutic areas
* Covers bioassays that measure toxicity, including those for chemical toxicity and hepatoxicity–a particularly significant consideration in the development of safe and tolerable medications
* Highlights clinically relevant methods, ideas, and techniques to support any -pharmaceutical researcher
* Suggests guidelines and systems to enhance communication between -pharmacologists, chemists, and biologists
* Provides an informative analysis of pharmaceutical bioassay technologies and lab applications
Table of Content
Preface xxi
Contributors xxiii
1 Methods and Applications of Anticancer Bioassays 1
Shiqi Peng
2 Methods and Applications of Antiviral Assays 23
Shiqi Peng, Ming Zhao, and Chunying Cui
3 Methods and Applications of Antitubercular Assays 39
Shiqi Peng, Ming Zhao, and Chunying Cui
4 Methods and Applications of Thrombus-Related Assays 45
Ming Zhao
5 Methods and Applications of Anticoagulation Assays 65
Ming Zhao
6 Methods and Applications of Blood Pressure-Related Assays 87
Ming Zhao
7 Methods and Applications of Assays Related to Parkinson’s Disease and Graves’ Disease 101
Shiqi Peng
8 Methods and Applications of Alzheimer’s Disease Assays 125
Shiqi Peng
9 Methods and Applications of Antiosteoporosis Assays 145
Ming Zhao
10 Methods and Applications of Immunomodulating Assays 157
Shiqi Peng
11 Methods and Applications of Anti-Inflammatory Assays 187
Ming Zhao
12 Methods and Applications of Antioxidant Activity Assays 205
Shiqi Peng
13 Methods and Applications of Analgesic Assays 223
Ming Zhao
14 Methods and Applications of Epilepsy Assays 237
Ming Zhao, Shiqi Peng, and Guohui Cui
15 Methods and Applications of Diabetes Assays 251
Ming Zhao, Shiqi Peng, and Guohui Cui
16 Methods and Applications of Assays for Toxins from Microorganisms 259
Shiqi Peng
17 Methods and Applications of Toxicity Assays for Chemicals 281
Shiqi Peng
18 Methods and Applications of Hepatoxicity and Hepatoprotective Assays 325
Shiqi Peng
19 Methods and Applications of Estrogen Assays 373
Shiqi Peng
20 Methods and Applications of Antimalarial Assays 397
Shiqi Peng
21 Methods and Applications of Cytogenetic Receptor and Enzyme Assays 419
Shiqi Peng
Index 445
About the author
SHIQI PENG is a Professor and Dean at the School of Chemical Biology and Pharmaceutical Sciences of Capital Medical University in Beijing. He is the author of over 220 journal articles, seven books in China, and over 110 Chinese patents.
Ming Zhao is a Professor and Vice Dean at the School of Chemical Biology and Pharmaceutical Sciences of Capital Medical University in Beijing. She is the author of over 120 journal articles, seven books in China, and over 110 Chinese patents.
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