The story of success goes on and on – with a new book on combinatorial chemistry, edited by Günther Jung!
Combinatorial chemistry is a proven time- and resource-saving synthetic method of outstanding importance for industrial processes. Compound libraries help to save time and money, especially in the search for new drugs, and therefore play a pivotal role in solving the problem of the worldwide increasing demand for new and more active drugs. Not only substances, which are of interest for pharmaceutical chemistry, but also materials, catalysts, and biomolecules such as DNA or oligosaccharides are readily available with high structural diversities. The broad scope of combinatorial sciences is reflected by this book, edited by Günther Jung: The synthetic methods discussed range from solid-phase to solution-phase synthesis, from preparations of small molecules such as amines or alcohols to those of complex biomolecules. Feasible methods, efficient techniques, new trends in automation, and state-of-the-art fast instrumental analytical and screening methods are presented with many practical tips and tricks for everybody working in combinatorial chemistry.
This is the book written by specialists for specialists and for everyone aspiring to become an insider! It is an indispensible source of information for researchers working in organic synthesis, catalysis, biochemistry, and biotechnology, pharmaceutical and clinical chemistry, material sciences, and analytical chemistry.
สารบัญ
Combinatorial Chemistry
Survey of Solid Phase Organic Reactions
Solution Phase Combinatorial Chemistry
Combinatorial Chemistry of Multicomponent Reactions
Solid Phase Anchors in Organic Chemistry
The Use of Templates in Combinatorial Chemistry for Solid Phase Synthesis of Multiple Core Structure Libraries
Combinatorial Synthetic Oligomers
Glycopeptide and Oligosaccharide Libraries
RNA and DNA Aptamers
Combinatorial Approaches to Molecular Receptors for Chemosensors
Peptide Libraries in T-Cell Mediated Immune Response
Combinatorial Biosynthesis of Microbial Metabolites
Design and Diversity Analysis of Compound Libraries for Lead Discovery
How to Scale-up While Scaling Down: EVOscreen, a Miniaturized Ultra High Throughput Screening System
High Throughput Experimentation in Catalysis
FT-Infrared Spectroscopy and IR-Microscopy for On Bead Analysis of Solid Phase Synthesis
High-Resolution Magic Angle Spinning NMR Spectroscopy of On-Bead Analysis of Solid Phase Synthesis
Mass Spectrometric Analysis of Organic Compound Collections
Automation in Combinatorial Synthesis
Ion-Cyclotron-Resonance-FT-Mass Spectrometry for Elemental Composition Analysis of Library Components
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