This text is designed to provide readers with a useful and comprehensive resource and state-of-the-art overview about the new, growing and fast-expanding field of “liquid biopsy” for the management of cancer patients. The liquid biopsy represents an important turning point in oncology since it provides a tool for a serial monitoring of disease. Liquid biopsy is our “hand lens” to follow molecular changes that characterize tumor development and progression. The book provide a unique and valuable resource on the clinical relevance of liquid biopsy as well as on the technical aspects of liquid biopsy analysis. All invited authors are recognized experts in their field.
Liquid Biopsy in Cancer Patients: The Hand Lens for Tumor Evolution is targeted to resident and fellows physicians, medical oncologists, molecular biologists and biotechnologists.
Table of Content
Introduction.- Precision Medicine: Are We There?.- Clonal Cancer Evolution and Intra-tumor Heterogeneity.- Tissue vs. Liquid Biopsy: Opposite or Complementary?.- Technical Aspects for the Evaluation of Circulating Tumor Cells (CTCs).- Technical Aspects for the Evaluation of Circulating Nucleic Acids (CNA): Circulating Tumor DNA (ct DNA) and Circulating Micro RNAs.- Technical Aspects for the Evaluation of Exosome and their Content.- Liquid Biopsy in Breast Cancer.- Liquid Biopsy in Head and Neck Cancers.- Liquid Biopsy in NSCLC.- Liquid Biopsy in Gastric Cancer.- Liquid Biopsy in Pancreatic Cancer.- Liquid Biopsy in HCC.- Liquid Biopsy in CRC.- Liquid Biopsy in GIST.- Liquid Biopsy in Kidney Cancer.- Liquid Biopsy in Melanoma.
About the author
Antonio Giordano, MD, Ph D Director Sbarro Institute for Cancer Research and Molecular Medicine and Center of Biotechnology College of Science and Technology Temple University Bio Life Science Bldg. Suite 431 1900 N 12th Street Philadelphia PA 19122 Usa Tel: +1 215-204 9520 Fax: +1 215-204 9522 E-mail: [email protected]@shro.org
Antonio Russo, MD, Ph D
Professor of Medical Oncology Section of Medical Oncology Department of Surgical and Oncological Sciences School of Medicine, University of Palermo, Via del Vespro 129 – 90127 Palermo (Italy) Adjunct Full Professor in Temple University, Institute for Cancer Research and Molecular Medicine and Center of Biotechnology – College of Science and Biotechnology, Philadelphia (USA) Phone: + 39-091-6552500; Fax: +39-091-6554529 E-mail: [email protected]
Christian Rolfo, MD, Ph DHead of Unit Phase I – Early Clinical Trials Director of Clinical Trial Management Program Oncology Department University Hospital Antwerp UZA, Wilrijkstraat 10, 2650 Edegem Tel +32 3 821 3646E-mail: [email protected]
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