This book constitutes the refereed proceedings of the 12th International Conference entitled Beyond Databases, Architectures and Structures, BDAS 2016, held in Ustron, Poland, in May/June 2016.It consists of 57 carefully reviewed papers selected from 152 submissions. The papers are organized in topical sections, namely artificial intelligence, data mining and knowledge discovery; architectures, structures and algorithms for efficient data processing; data warehousing and OLAP; natural language processing, ontologies and semantic Web; bioinformatics and biomedical data analysis; data processing tools; novel applications of database systems.