Central to this volume, and critical to its unique creative significance and contribution, is the conceptual unification of syndemics and stigma. Syndemics theory is increasingly recognized in social science and medicine as a crucial framework for examining and addressing pathways of interaction between biological and social aspects of chronic and acute suffering in populations. While much research to date addresses known syndemics such as those involving HIV, diabetes, and mental illness, this book explores new directions just beginning to emerge in syndemics research revealing what syndemics theory can illuminate about, for example the health consequences of socially pathologized pregnancy or infertility, when stigmatization of reproductive options or experiences affect women’s health. In other chapters, newly identified syndemics affecting incarcerated or detained individuals are highlighted, demonstrating the physical, psychological, structural, and political-economic effects of stigmatizing legal frameworks on human health, through a syndemic lens. Elsewhere in the volume, scholars examine the stigma of poverty and how it affects both nutritional and oral health. The common thread across all chapters is linkages of social stigmatization, structural conditions, and how these societal forces drive biological and disease interactions affecting human health, in areas not previously explored through these lenses.