Damir Janigro & Astrid Nehlig 
Inflammation and Epilepsy: New Vistas [PDF ebook] 

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This book provides comprehensive information, both for clinicians and scientists, on the basic mechanisms, clinical features, and therapeutic approaches to epilepsy as an inflammatory disease. Inflammation has been for many years considered as an etiologic player (and a therapeutic target) for a specific group of epilepsies. However, it turns out that this concept underestimated the impact of inflammation in seizure disorders. Many accepted therapies for non-inflammatory epilepsies act in part as an inflammatory drug. The CNS actively responds to acute immune challenges by altering body temperature, stimulating the HPA axis, as well as up- and down-regulating specific sympathetic pathways.

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Table of Content

Pro and Anti-Inflammatory Neurovascular Processes in Epilepsy: A Fragile and Dynamic Equilibrium.- Emerging Molecular Mechanisms of Neuroinflammation in Seizure Disorders.- Glial Mechanisms of Inflammation during Seizures.- Perivascular Inflammation and Extracellular Matrix Alterations in Blood-Brain Barrier Dysfunction and Epilepsy.- Blood T cells and Cytokine Levels during Interictal-Ictal Transitions.- Autoantibodies, Encephalopathies and Epilepsy.- Tau Protein in Drug-Resistant Epilepsy and Cognitive Decline.- Ketogenic Diet, Inflammation and Epilepsy.- Role of Regulatory T cells in Epilepsy.- Inflammation at the Neurovascular Unit in Post-Traumatic Epilepsy.

About the author

Damir Janigro
Department of Physiology and Biophysics Case Western Reserve University

Cleveland
Ohio USA

 
Astrid Nehlig
INSERM
Strasbourg
France
    
Nicola Marchi
Cerebrovascular and Glia Research, Department of Neuroscience
Institute of Functional Genomics
Montpellier,
France

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Language English ● Format PDF ● Pages 237 ● ISBN 9783030674038 ● File size 5.0 MB ● Editor Damir Janigro & Astrid Nehlig ● Publisher Springer International Publishing ● City Cham ● Country CH ● Published 2021 ● Downloadable 24 months ● Currency EUR ● ID 7844727 ● Copy protection Social DRM

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