Digital transformation continues to accelerate change in all aspects of modern life. This book examines when, where, how, and why artificial intelligence and digital change can boost innovation and transform the economy, society and democracy. It provides a holistic approach to the promotion of the knowledge economy, knowledge society and knowledge democracy.The book is developed based on the Cyber-D4 nexus, which is a conceptual framework of Cyber-Defense, Cyber-Development, Cyber-Democracy, and Cyber-Diplomacy, and it adopts a Quadruple/Quintuple Innovation Helix (Q2IH) approach. This nexus ties new national and industrial cyber strategies, including business strategies for smart cities and the Internet of Things, with the local, national, regional, and global security and economic objectives.Academics, policy makers, practitioners, researchers and students in combined fields of science, technology, innovation and entrepreneurship, digital transformation, artificial intelligence and the future of industry will appreciate the lens through which the chapter authors explore both the minutiae and expansive influence of digital transformation.