This volume examines the state-of-the-art in our understanding of the aging brain through the application of brain imaging techniques of neuroscience to the geriatric population. By exploring the neurobiological aspects of geriatric mental health, scientists can begin to understand why abnormal aging happens and what can be done to treat it.
Researchers in the fields of geriatric psychiatry, cognitive neuropsychology, neurology, neuroradiology, and physics have combined their expertise to present this accessible, compact review of the field. The chapter authors discuss the use of image modalities and what they can tell us about the aging brain; and present cutting-edge information on image processing and data analysis in the context of geriatric populations. With this book, both novice and seasoned investigators can gain fresh, new insight into geriatric mental health.- The use of MRI (magnetic resonance imaging), MRS (magnetic resonance spectroscopy), and other modalities with geriatric populations
- Single photon emission computed tomography) and PET (positron emission tomography) to geriatric mental health
- Structural brain changes associated with normal aging
- Functional neuroanatomy of aging and cognition
- Brain structural and functional correlates of Alzheimerís dementia and mild cognitive impairment
- Neuroimaging in late-life schizophrenia
Inhaltsverzeichnis
I INTRODUCTION
1.The Expanding Role of Neuroimaging Research in Geriatric Psychiatry
II. IMAGING MODALITIES
2. Computed Tomography (CT)
3.Magnetic Resonance Imaging (MRI)
4. Magnetic Resonance Spectroscopy (MRS)
5. Single Photon Emission Computed Tomography (SPECT)
6. Positron Emission Tomography (PET)
7. Functional MRI
III IMAGE PROCESSING
8. Volumetric analyses of structural imaging data: VBM and ROI-based approaches
9. Atrophy Correction for functional imaging analyses
10. Common Pitfalls in f MRI analyses
11. Software Packages
IV AGING
12. Structural brain changes associated with normal aging
13. The HAROLD model of neurocognitive aging
14. New insights into the functional neuroanatomy of aging
V AFFECTIVE DISORDERS
15. Vascular Depression Hypothesis
16. Hippocampal Changes with Depression
17. White matter abnormalities in geriatric depression
18. Late-life bipolar disorder
VI COGNITIVE DISORDERS
19. Alzheimer’s Disease
20. Vascular Dementia
21. Frontotemporal Dementia
22. Mild Cognitive Impairment
23. Functional Imaging changes with dementia
24. Early detection and monitoring of AD with MRI: the ADNI project
VII PSYCHOTIC DISORDERS
25. Late-Life Schizophrenia
26. Psychosis of Dementia
VIII NEW IMAGING MODALITIES
27. Diffusion Tensor imaging (DTI)
28. Magnetic Resonance Spectroscopy
29. Magnetization Transfer Ratio (MTR)
30. Amyloid imaging
Über den Autor
Howard J. Aizentstein, MD, Ph D is an assistant professor of psychiatry at the University of Pittsburgh Medical School and Director of its Geriatric Psychiatry Neuroimaging Laboratory.
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