Cutting-edge articles review our current understanding of lipid microdomain signaling mechanisms and their physiological and pathological importance. The book describes the role of lipid rafts in learning, memory, and cancer, presents the emerging evidence that lipid rafts play critical roles in signaling pathways and the regulation of synaptic function in the nervous system, and shows how alterations in lipid raft metabolism are implicated in the pathogenesis of neurodegenerative disorders. Techniques are also described for the isolation of lipid rafts, the analysis of the lipid and protein components of lipid rafts, the imaging of lipid rafts in living cells, and the analysis of signal transduction in lipid rafts.
Inhaltsverzeichnis
From Intramolecular Asymmetries to Raft Assemblies.- Regulatory Aspects of Membrane Microdomain (Raft) Dynamics in Live Cells.- Lipid Raft Membrane Skeletons.- Role of Cholesterol in Membrane Microdomain Signaling.- Raft Lipid Metabolism in Relation to Alkyl-Lysophospholipid-Induced Apoptosis.- The Role of Lipid Rafts in Signal Transduction and Synaptic Plasticity of Neural Cells.- Role of Rafts in Virus Fusion and Budding.- Alterations in Raft Lipid Metabolism in Aging and Neurodegenerative Disorders.- Caveolin and Cancer.- Dietary Modulation of Lipid Rafts.
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