The three-volume set LNICST 465, 466 and 467 constitutes the proceedings of the Second EAI International Conference on Application of Big Data, Blockchain, and Internet of Things for Education Informatization, Big Io T-EDU 2022, held as virtual event, in July 29-31, 2022. The 204 papers presented in the proceedings were carefully reviewed and selected from 550 submissions. Big Io T-EDU aims to provide international cooperation and exchange platform for big data and information education experts, scholars and enterprise developers to share research results, discuss existing problems and challenges, and explore cutting-edge science and technology. The conference focuses on research fields such as "Big Data" and "Information Education. The use of Artificial Intelligence (AI), Blockchain and network security lies at the heart of this conference as we focused on these emerging technologies to excel the progress of Big Data and information education.