For more than one hundred years of their institutionalization, cultural studies or Kulturwissenschaften and semiotics have enabled, through the connectivity of their theories and methods, an inter- and transdisciplinary research practice, particularly conspicuous today in research topics shared by semiotics and naturalcultural studies or Naturkulturwissenschaften. The contributions to the collection mark waypoints towards a systematic mapping of the wide range and history of exchange of terminologies and models between Kulturwissenschaften or cultural studies and semiotics. They record the epistemological advantages of making the continuing convergence explicit for future research and as the task of a critical methodology.