Providing an integrated approach to the diagnosis and management of patients with metastatic bone disease (MBD), this comprehensive text combines discussion of the pathobiology of the disease with the latest oncological and orthopedic treatment modalities. After opening with an examination of the epidemiology and impact of MBD, the biology of bone metastases are discussed, along with considerations of the tissue of origin. Evaluation, biopsy and medical therapy, including metabolic agents and bio targeting. The heart of the book presents oncological approaches (supportive, radiation and interventional) and principles of orthopedic surgical oncology, with subsequent chapters covering specific anatomy, from the pelvis to the lower extremity and the spine. Chapters on emerging surgical technology and future directions conclude the text and redefine an integrated approach to patient care. Taken together, Metastatic Bone Disease is an excellent resource for orthopedic surgeons andcancer specialists alike.
Inhaltsverzeichnis
Part One: The Problem.- Bone Metastases: Epidemiology and Societal Effect.- Part Two: Biology of Metastases and Tissue of Origin Considerations.- Pathobiology of Osteolytic and Osteoblastic Bone Metastases.- Biology of Bone Cancer Pain.- Breast Cancer Bone Metastases.- Prostate Cancer Bone Metastasis.- Lung.- Kidney Metastatic Bone Disease.- Thyroid.- Myeloma.- Part Three: Work-Up for Patients with Suspected Metastatic Bone Disease.- Evaluation of the Patient with Carcinoma of Unknown Origin Metastatic to Bone.- Biopsy Considerations.- Part Four: Medical Therapy.- Bisphosphonates, Denosumab and Anabolic Agents in the Treatment of Metastatic Bone Disease.- Biotargeting in Metastatic Bone Disease.- Part Five: Supportive Oncology.- Psychosocial Considerations for Patients with Metastatic Bone Disease.- Pain Management in Metastatic Bone Disease.- When is Hospice Appropriate? The Role for Hospice in Palliating Patients with Bone Metastases.- Part Six: Radiation Oncology.- Current and Emerging Modalities.- Part Seven: Interventional Oncology.- Ablation and Cementation Technologies.- Part Eight: Principles of Orthopaedic Surgical Oncology.- Issues Facing the Established Metastatic Bone Disease Patient, Timing/Indications for Surgery.- Questions to Ask Your Medical Oncology Colleagues.- Consideration of the Temporal Relationship between Surgery and Radiation Therapy.- Role of Surgery in Oligometastatic Disease.- Part Nine: Specific Anatomic Considerations for Surgery.- Metastatic Bone Disease: Pelvis.- Metastatic Bone Disease: Femur.- Metastatic Bone Disease: Femur: Tibia.- Metastatic Bone Disease: Foot.- Metastatic Bone Disease: Femur: Humerus, Scapula.- Metastatic Bone Disease: Forearm, Hand.- Metastatic Bone Disease: Spine.- Part Ten: Emerging Surgical Technologies.- Intraoperative Imaging and Navigation.- Part Eleven: Putting It All Together.- Integrative Approach with the Patient in Mind: A Glance Forward.
Über den Autor
R. Lor Randall, MD, FACS, The L.B. & Olive S. Young Endowed Chair for Cancer Research Director, Sarcoma Services & Medical Director, HCI Surgical Services Chief, SARC Lab & Fellowships Co-Leader, Sarcoma Disease Oriented Research Team, Professor of Orthopaedics, Primary Children’s Hospital & Huntsman Cancer Institute, The University of Utah Salt Lake City, UT.
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