Metabolic engineering has been developed over the past 20 years to become an important tool for the rational engineering of industrial microorganisms. This book has a particular interest in the methods and applications of metabolic engineering to improve the production and yield of a variety of different metabolites. The overall goal is to achieve a better understanding of the metabolism in different microorganisms, and provide a rational basis to reprogram microorganisms for improved biochemical production.
Inhaltsverzeichnis
1. Towards Synthetic Gene Circuits with Enhancers: Biology’s Multi-input Integrators. - 2. Elementary Mode Analysis: A Useful Metabolic Pathway Analysis Tool for Reprograming Microbial Metabolic Pathways. – 3. Evolutionary Engineering for Industrial Microbiology. – 4. Monitoring Microbial Diversity of Bioreactors Using Metagenomic Approaches. - 5. Synthetic Biology Triggers New Era of Antibiotics Development. - 6. Cascades and Networks of Regulatory Genes That Control Antibiotic Biosynthesis. - 7. Systems Analysis of Microbial Adaptations to Simultaneous Stresses. – 8. Metabolic Reprogramming under Microaerobic and Anaerobic Conditions in Bacteria. - 9. Tunable Promoters in Synthetic and Systems Biology. - 10. Analysis of Corynebacterium glutamicum Promoters and Their Applications. - 11. Production of Fumaric Acid by Fermentation. - 12. Metabolic Engineering of Microorganisms for Vitamin C Production. - 13. Molecular Mechanisms and Metabolic Engineering of Glutamate Overproduction in Corynebacterium glutamicum. - 14. Microbial Metabolic Engineering for L-threonine Production. - 15. The Production of Coenzyme Q10 in Microorganisms. - 16. Genetic Modification and Bioprocess Optimization for S-adenosyl-L-methionine biosynthesis. - 17. Manipulation of Ralstonia eutropha Carbon Storage Pathways to Produce Useful Bio-based Products. - 18. Metabolic Engineering of Inducer Formation for Cellulase and Hemicellulase Gene Expression in Trichoderma reesei. - 19. Microbiologically Produced Carboxylic Acids Used as Building Blocks in Organic Synthesis.
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