Inflammatory bowel disease (IBD) comprises a group of idiopathic
diseases of the intestine characterized by chronic inflammation of
the bowel with periods of exacerbation and remission. Although the
exact cause of IBD remains undetermined, the condition appears to
be related to a combination of genetic and environmental factors
resulting in an aberrant activation of the mucosal immune system.
This book contains a series of interdisciplinary discussions
between clinical and basic scientists focusing on key issues such
as:
* Epithelial cell and molecular biology, including apoptosis,
necrosis and cell survival
* The role of bacterial milieu and mucosal bacteria in the IBD
and of prebiotic and probiotic therapy
* The progress towards the identification of susceptibility genes
and phenotype-determining genes
* The pharmacogenetics of IBD
* Mucosal immunology and therapeutic strategies stemming
therefrom
Table of Content
Chair’s Introduction (Jewell).
Progress toward identifying inflammatory bowel disease
susceptibility genes (Rioux).
Phenotype-determining genes in inflammatory bowel disease
(Ahmad).
Pharmacogenetics of inflammatory bowel disease (Kelleher et
al).
Bacterial milieu and mucosal bacteria in ulcerative colitis
(Macfarlane et al).
Defensins and mucosal protection (Mahid and Cunliffe).
Intestinal mycoplasma in Crohn’s Disease (Roediger).
Kong Probiotics, prebiotics and antibiotics in inflammatory
bowel disease (Cummings and Choon).
The eipthelium in inflammatory bowel disease: potential role of
endocytosis of junctional proteins in barrier disruption (Ivanov et
al).
Apoptosis or necrosis – colonic epithelial cell survival
(Gibson).
Genetic aspects of intestinal permeability in inflammatory bowel
disease (Takeuchi et al).
Animal models of intestinal inflammation: clues to the
pathogenesis of inflammatory bowel disease (Powrie and Uhlig).
Homing of intestinal immune cells (Uhlig et al).
Anti-TNF therapy in Crohn’s Disease (Ghosh).
Index of contributors.
Subject index.
About the author
Derek J. Chadwick and Jamie A. Goode are editors for Inflammatory Bowel Disease: Crossroads of Microbes, Epithelium and Immune Systems and other scientific titles.
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