With the recent renaissance in mitochondrial biology and increasing
recognition of their role in many diseases, this book provides a
timely summary of the current state-of-the-art in mitochondrial
research. The book opens with the regulation of mitochondrial
replication and biogenesis and reviews the mechanisms and
functional consequences of mitochondrial fission and fusion.
Further chapters address mitochondria and oxidative stress and
their roles in cell signalling and cell death. The book includes
extensive, fascinating discussion of the biochemistry of
mitochondrial cell signalling (especially involving calcium) and of
oxidative stress. The nature of the proteins engaged in these
processes, many only recently discovered, is covered in detail.
Mitochondria have been strongly implicated in neurodegenerative
diseases such as Parkinson’s, Huntington’s and
amyotrophic lateral sclerosis. They are also affected in cancer,
ageing and cardiovascular disease. The final section of the book
reviews mitochondrial mutations and their consequences in ageing
and other phenotypic manifestations. The authors discuss how
mitochondrial proteins might constitute important therapeutic
targets and describe initial attempts to develop compounds that can
regulate their function.
Table of Content
Symposium on New perspectives on mitochondrial biolog y, held at
the Novartis Foundation, London, 28-30 November 2006.
Editors: Derek J. Chadwick (Organizer) and Jamie Goode.
This symposium is based on a proposal by Michael Duchen.
David G. Nicholls Chair’s introduction.
Albert Neutzner, Richard J. Youle and Mariusz
Karbowski, Outer mitochondrial membrane protein degradation by
the proteasome.
Discussion.
Sarah E. Haigh, Gilad Twig, Anthony A. J. Molina, Jakob D.
Wikstrom, Motti Deutsch and Orian S. Shirihai
PA-GFP: a window into the subcellular adventures of the individual
mitochondrion.
Discussion.
Luca Scorrano, Multiple functions of mitochondria-shaping
proteins. Discussion.
Bruce M. Spiegelman, Transcriptional control of
mitochondrial energy metabolism through the PGC1
coactivators.
Discussion.
Charles Affourtit, Paul G. Crichton, Nadeene Parker and
Martin D. Brand, Novel uncoupling proteins.
Discussion.
Cecilia Giulivi, Mitochondria as generators and targets
of nitric oxide. Discussion.
György Hajnóczky, Masao Saotome, György
Csordás, David Weaver and Muqing Yi, Calcium
signalling and mitochondrial motility.
Discussion.
Anna Romagnoli, Paola Aguiari, Diego De Stefani, Sara
Leo, Saverio Marchi, Alessandro Rimessi, Erika Zecchini,
Paolo Pinton and Rosario Rizzuto, Endoplasmic
reticulum/mitochondria calcium cross-talk.
Discussion.
Brian O’Rourke, Sonia Cortassa, Fadi Akar and
Miguel Aon, Mitochondrial ion channels in cardiac function
and dysfunction.
Discussion.
Paolo Bernardi and Michael Forte, The
mitochondrial permeability transition pore.
Discussion.
Dominic James, Philippe A. Parone, Olivier Terradillos,
Safa Lucken-Ardjomande, Sylvie Montessuit and Jean-Claude
Martinou, Mechanisms of mitochondrial outer membrane
permeabilization.
Discussion.
M. Flint Beal, Mitochondria and neurodegeneration.
Discussion.
Mügen Terzioglu and Nils-Göran Larsson,
Mitochondrial dysfunction in mammalian ageing.
Discussion.
Eric A. Schon and Salvatore Di Mauro. Mitochondrial
mutations: genotype to phenotype.
Discussion.
Contributor Index.
Subject index.
About the author
The Novartis Foundation is an international scientific and
educational charity which promotes the study and general knowledge
of science and in particular encourages international co-operation
in scientific research.
Chairman: David G Nicholls, Buck Institute for Age Research,
Novato, USA.
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