Current heart failure therapeutics affects symptoms without
appreciably reducing the mortality rate of 50% in five years —
suggesting a failure in treating the underlying mechanism. This
book proposes a new mechanism for heart failure; immune mediated
cardiac remodelling for cardiac dysfunction.
The outstanding editor team of two internationally recognized
immunologists — Ronald Watson, who has studied heart disease in
immune dysfunction for a decade and has a patent for an
immunotherapy of heart disease by immune regulation, and Douglas
Larson, whose experience in cardiac transplantation immunology has
provided the foundation for research into novel therapeutics for
heart failure and hypertension – makes Immune Dysfunction and
Immunotherapy in Heart Disease the definitive reference to the
state of the science in this area.
The four parts of the book address:
* * Immune Dysfunction Leading to Heart Disease: Induction by
Physiological Changes
* Immune Dysfunction Promoting CVD: Induction by Transplantation
Drugs
* Immune Dysfunction Leading to Heart Dysfunction: Induction or
Prevention by Cardiotherapeutic Drugs
* Immune Dysfunction Leading to Heart Disease: Induction by
Pathogens
Both researchers and practitioners will find this authoritative
volume an excellent source of information on novel immune targeted
therapeutics.
Table of Content
PART 1: Immune Dysfunction Leading to Heart Disease: Induction by Physiological Changes.
01 Immunosuppression by Ultraviolet Light-B Radiation: a Mediator of Cardiac Remodeling.
02 Immune Mechanisms In Pediatric Cardiovascular Disease.
03 Heart failure – role of autoimmunity.
04 Immune basis of Hypertension in Humans.
05 Immune Dysregulation: Potential Mediator of Metabolic Syndrome-Induced Cardiac Remodeling.
06 T-Helper 2 Cell Cytokines In Remodelling Of Aortic Wall.
07 Effects of TNF-alpha on Cardiac Function.
08 Immunosuppression in Promotion of Cardiac Allograft Vasculopathy.
09 Immunotherapy for left ventricular dysfunction after heart transplantation.
PART 2: Immune Dysfunction Promoting CVD: Induction by Transplantation Drugs.
10 Immunmodulating therapy in chronic heart failure.
11 Statins in Atherosclerosis: Role of Immune Regulation.
12 ACE Inhibitors as Immunmodulators: Treatment of Cardiovascular Disease.
13 Treatment of Heart Failure by Anticytokine Therapies.
PART 3: Immune Dysfunction Leading to Heart Dysfunction: Induction or prevention by Cardiotherapeutic Drugs.
14 Pathogenesis Of Cardiovascular Complications In The Acquired Immunodeficiency Syndrome.
15 Cytokines and T cell-Mediated Responses in Autoimmune Myocarditis.
16 Drugs of abuse: Accentuation of immunomodulation of viral myocarditis.
PART 4: Immune Dysfunction Leading to Heart Disease: Induction by Pathogens.
17 Osteopontin: The link between the Immune System and cardiac remodeling.
18 Inflammatory immune activation in heart failure patients;
Therapeutic implications.
19 Role of Innate Immune Dysregulation in Diabetic Heart Failure.
20 Tolerance in Heart Transplantation: Current and Future Role.
21 Neutralization of Th2 cytokines in therapy of cardiovascular pathology.
22 Anti-inflammatory immune therapy in heart disease.
23 Cholesterol Synthesis, Interleukin 6 inflammation and Atherosclerosis –
Role of statins, bisphosphonates and plant polyphenols in Atherosclerosis and other diseases of Aging.
24 Autoimmune myocarditis. Treatment with anti-T-cell antibodies.
25 Immunosuppressive Therapy To Counter Cardiac Allograft Vasculopathy.
26 Immunosuppression by Ultraviolet Light-B Radiation: a Mediator of Cardiac Remodeling.
27 Role of oral pathogens in the pathogenesis of coronary heart disease.
28 Myocardial regenerative potential by stem cell transplant.
29 Bioflavanoids and Dietary Anti-Inflammatory Actions: Role in Cardiovascular Diseases
About the author
Dr. Larson and Dr. Watson have worked together researching the role
of immune and cytokine dysfunction in heart disease for 8 years.
They have been and currently are funded to do such research by
grants from the U.S. National Institute of Heart, Lung and Blood,
the American Heart Foundation, companies and private foundations.
Dr. Watson has edited 62 scientific books, including several
dealing with heart disease and conditions such as aging and AIDS
that promote immune dysfunction as well as heart disease. Dr.
Larson directs the Center’s organ perfusion program as well
as its Master degree in pharmacology and toxicology for perfusion
students.
____________________________________________________________________
Ronald Ross Watson Ph.D.
Professor Health Promotion Sciences, Mel and Enid Zuckerman
College of Public Health and the Sarver Heart Center in the School
of Medicine, University of Arizona, P. O. Box 245155, 1501 N.
Campbell Avenue, Tucson, AZ 85749.
(520) 626 2850, Fax (520) 626 6093 [email protected]
____________________________________________________________________
Douglas F. Larson Ph.D.
Professor Surgery and the Sarver Heart Center in the School of
Medicine, University of Arizona, P. O. Box 245066, 1501 N. Campbell
Avenue, Tucson, AZ 85749. (520) 626 6494
[email protected]
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