Ayman (University of Louisville, Kentucky, USA) El-Baz & Jasjit S. (Global Biomedical Technologies, Inc., Roseville, USA) Suri 
Level Set Method in Medical Imaging Segmentation [PDF ebook] 

Level set methods are numerical techniques which offer remarkably powerful tools for understanding, analyzing, and computing interface motion in a host of settings. When used for medical imaging analysis and segmentation, the function assigns a label to each pixel or voxel and optimality is defined based on desired imaging properties. This often includes a detection step to extract specific objects via segmentation. This allows for the segmentation and analysis problem to be formulated and solved in a principled way based on well-established mathematical theories. Level set method is a great tool for modeling time varying medical images and enhancement of numerical computations.