This book constitutes the proceedings of the 13th International Conference on Security and Cryptography for Networks, SCN 2022, held in Amalfi, Italy, in September 2022.The 33 full papers presented in this volume were carefully reviewed and selected from 101 submissions. They are organized in topical sections: Ciphers, Cryptanalysis, Defenses; Public Key Encryption; Authentication and Signatures, Multiparty Computation; Zero-Knowledge Proofs and Applications.