This completely updated and expanded 2nd edition of Systemic Lupus Erythematosus, A Manual includes topics not covered previously with contributors who are at the forefront of each specific topic and with a global appeal. Each chapter is short and is presented critically with selected references, which should be valuable to a wider audience. This book combines basic with clinical science to help internists and specialists in the diagnosis and management of patients with SLE. It is a quick referral for people in the pharmaceutical industry in their efforts to bring much-needed drugs. It provides all the needed information to basic researchers old and new alike, who wish to enter the field of lupus and systemic autoimmunity in general. – Focused state-of-the-art chapters prepared by top-notch experts in the field- Latest understanding of cellular, molecular, biochemical aspects of disease pathogenesis- Advanced aspects of genetic, microbiome, environmental, hormonal, and immunological contribution to the expression of the disease- Current understanding of clinical features of the disease- Recent efforts to develop new treatments