To understand the brain and its devastating diseases, we need to
reveal the mechanisms that produce it and the ways in which it can
constantly change throughout a lifetime. This book features a
timely and insightful discussion between developmental
neurobiologists and clinicians who deal with disorders of the
nervous system.
Chapters in this book deal specifically with cell fate
determination, cell migration and disorders of cell migration;
current concepts and new ideas about cortical arealisation, and
disorders which can arise from incorrect arealisation; genes
implicated in the development of cortical connectivity and related
pathologies such as schizophrenia and synaesthesia; and
susceptibility genes for cognitive disorders such as schizophrenia,
autism, dyslexia, and attention deficit disorder.
Tabla de materias
Symposium on Cortical development: genes and genetic abnormalities,
held at the Novartis Foundation, London, 6-8 February 2007.
Editors: Gregory Bock (Organizer) and Jamie Goode.
This symposium is based on a proposal made by Zoltán
Molnár.
John G. Parnavelas Chair’s introduction.
Bradley J. Molyneaux, Paola Arlotta and Jeffrey D.
Macklis/Molecular development of corticospinal motor neuron
circuitry.
Gordon Fishell /Perspectives on the developmental origins
of cortical interneuron diversity.
Pasko Rakic, Kazue Hashimoto-Torii and Matthew R.
Sarkisian /Genetic determinants of neuronal migration in the
cerebral cortex.
Stephen C. Noctor, Veronica Martinez-Cerdeño and
Arnold R. Kriegstein /Neural stem and progenitor cells in
cortical development.
Teresa H. Chae and Christopher A. Walsh /Genes
that control the size of the cerebral cortex.
Vicki Hammond, Joanne Britto, Eva So, Holly Cate and
Seong-Seng Tan /Control of cortical neuron layering: lessons
from mouse chimeras.
Fujio Murakami, Daisuke Tanaka, Mitsutoshi Yanagida and
Emi Yamazaki /Intracortical multidirectional migration of
cortical interneurons.
Libing Zhou, Fadel Tissir and André M.
Goffinet /The atypical cadherin Celsr3 regulates the
development of the axonal blueprint.
Dennis D. M. O’Leary , Shen-Ju Chou, Tadashi
Hamasaki, Setsuko Sahara, Akihide Takeuchi, Sandrine
Thuret and Axel Leingärtner /Regulation of laminar
and area patterning of mammalian neocortex and behavioural
implications.
Jeremy A. Cholfin and John L. R. Rubenstein
/Genetic regulation of prefrontal cortex development and
function.
Henry Kennedy, Rodney Douglas, Kenneth Knoblauch and
Colette Dehay /Self-organization and pattern formation in
primate cortical networks.
Nobuhiko Yamamoto, Takuro Maruyama, Naofumi Uesaka,
Yasufumi Hayano, Makoto Takemoto and Akito Yamada
/Molecular mechanisms of thalamocortical axon targeting.
Zoltán Molnár, Anna Hoerder-Suabedissen, Wei Zhi
Wang, Jamin De Proto, Kay Davies, Sheena Lee, Erin C.
Jacobs, Anthony T. Campagnoni, Ole Paulsen, Maria Carmen
Piñon and Amanda F. P. Cheung /Genes involved in
the formation of the earliest cortical circuits.
Michael Piper, Amber-Lee S. Dawson, Charlotta Lindwall, Guy
Barry, Céline Plachez and Linda J. Richards
/Emx and Nfi genes regulate cortical development and
axon guidance in the telencephalon.
Paul J. Harrison /Schizophrenia susceptibility genes and
their neurodevelopmental implications: focus on neuregulin.
Peter B. Crino /Focal brain malformations: a spectrum of
disorders along the m TOR cascade.
Index of contributors.
Subject Index.
Sobre el autor
The Novartis Foundation is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research.
Chair: John Parnavelas, University College London, UK.
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