Autor: H. Koprowski

Ever since arbovirus infections became known and their relative importance assessed, experiments were designed to elucidate the mode of transmission and the most important natural hosts responsible f …

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"When we give a definition it is for the purpose of using it". HENRI POINCARE in Science and Method A. Objectives The first version of this paper was written to introduce new students and f …

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The expression of many bacterial genes adapts itself in an almost in- stantaneous and reversible way to specific environmental changes. More specifically, the concentration of a number of metabolites …

Phenomena as diverse as tuberculin sensitivity, delayed sensitivity to soluble proteins other than tuberculin, contact allergy, homograft rejection, experimental autoallergies, and the response to ma …

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Influenza continues to be one of the major epidemic diseases of man and is, in fact, his only remaining pandemic disease (BEVERIDGE, 1969). This is largely because influenza virus undergoes extreme a …

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At the end of the last century and the beginning of this century, the prob- lems of immunity in lower vertebrates and the influence of environmental temperature attracted attention for the first time …

General aspects of nucleic acid uptake by mammalian cells have been the subject of several reviews during the last few years (PAGANO, 1970; BHARGAVA and SHANMUGAM, 1971; DUBES, 1971; RYSER, 1967). Th …

This volume is dedicated to the memory of the late Professor WERNER BRAUN, one of the most devoted and active members of the Editorial Board of the Current Topics in Microbiology and Immunology, who …

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Prominent progress in molecular biology was only made when it became possible to separate functionally distinct molecules by taking advantage of their biophysical properties. Likewise, the analysis o …

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The processes involved in herpesvirus replication, latency, and oncogenic transformation, have, in general, been rather poorly defined. A primary reason for this is the size and complexity of the her …

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Expression of an immune response is the net result of complex synergis- tic and antagonistic activities performed by a variety of cell types. It includes macrophages, T and B populations which may in …

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The study of the genetic regulation of immune response to natural multidetermi- nant immunogens was undertaken by the method of bidirectional selective breed- ing of High or Low antibody responder li …

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Several discoveries are noteworthy for allowing us to probe the recesses of the virus- infected cell and to search for cryptic viral genomes which might provide clues in our studies of cancer etiolog …

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Binding of various ligands (hormones, neurotransmitters, immunological stimuli) to membrane receptors induces the following changes: 1. Receptor redistribution (clustering, "capping") 2. Co …

1. 1 Scope of the Review This review was intended initially as a reference source for those interested in the origins and f ITst descriptions ofthe defective avian sarcoma viruses. Quite a few of the …

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Rabies-as in former times-is still today a major killer affecting man and animals especially in many tropical and sub-tropical countries of Asia, Africa and South America. Some 50, 000 people and lit …

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All multicellular organisms may possess innate immunity mediated by defense mechanisms with which the organism is born. In recent years much has been learned about the diversity of innate immune mech …