This book constitutes the refereed proceedings of the 11th International Conference on Decision and Game Theory for Security, Game Sec 2020, held in College Park, MD, USA, in October 2020. Due to COVID-19 pandemic the conference was held virtually The 21 full papers presented together with 2 short papers were carefully reviewed and selected from 29 submissions. The papers focus on machine learning and security; cyber deception; cyber-physical systems security; security of network systems; theoretic foundations of security games; emerging topics.