Wiley is proud to announce the publication of the first ever broad-based textbook introduction to Bioinformatics and Functional Genomics by a trained biologist, experienced researcher, and award-winning instructor. In this new text, author Jonathan Pevsner, winner of the 2001 Johns Hopkins University ‘Teacher of the Year’ award, explains problem-solving using bioinformatic approaches using real examples such as breast cancer, HIV-1, and retinal-binding protein throughout. His book includes 375 figures and over 170 tables. Each chapter includes: Problems, discussion of Pitfalls, Boxes explaining key techniques and math/stats principles, Summary, Recommended Reading list, and URLs for freely available software. The text is suitable for professionals and students at every level, including those with little to no background in computer science.
Tabla de materias
PART I: ANALYZING DNA, RNA, AND PROTEIN SEQUENCES IN DATABASES.
1. Introduction.
2. Access to Sequence Data and Literature Information.
3. Pairwise Sequence Alignment.
4. Basic Local Alignmnet Search Tool (BLAST).
5. Advanced BLAST Searching.
PART II: GENOMEWIDE ANALYSIS OF RNA AND PROTEIN.
6. Bioinformatic Approaches to Gene Expression.
7. Gene Expression: Microarrays Data Analysis.
8. Protein Analysis and Proteomics.
9. Protein Structure.
10. Multiple Sequence Alignment.
11. Molecular Phylogeny and Evolution.
PART III: GENOME ANALYSIS.
12. Completed Genomes and the Tree of Life.
13. Completed Genomes: Viruses.
14. Completed Genomes: Bacteria and Archaea.
15. Eukaryotic Genomes: Fungi
16. Eukaryotic Genomes: From Parasites to Primates.
17. The Human Genome.
18. Human Disease.
Epilogue.
Appendix: GCG for Protein and DNA Analysis.
Glossary.
Solutions to Self-Test Quizzes.
Subject Index.
Author Index.
Sobre el autor
Jonathan Pevsner received his Ph.D. in Pharmacology and Molecular Sciences at the Johns Hopkins School of Medicine (1989). There, he identified an odorant-binding protein in nasal secretions. He completed postdoctoral training as a Helen Hay Whitney fellow in the Department of Molecular Physiology at the Stanford University Medical Center. At Stanford he identified proteins that function in neurotransmitter release at nerve terminals. In 1995 he joined the faculty in the Department of Neurology at the Kennedy Krieger Institute and the Department of Neuroscience at the Johns Hopkins School of Medicine. He began teaching bioinformatics in 1996, and introduced a ten-week course in 2000. In 2001 the graduate students voted him Teacher of the Year, and in 2003 the Johns Hopkins faculty gave him the Professor’s Award for Excellence in Teaching. His lab studies the molecular basis of childhood neurological disorders including autism and Down Syndrome, and develops bioinformatics software.
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