This book presents a thorough and critical review of current knowledge on the role of immunology in major psychiatric disorders and its potential applications. The opening chapters offer general information on the immune influence of the brain to provide readers with a better understanding of the end of immune privilege. The book then examines possible underlying mechanisms leading to psychiatric disorders, from early infections to pro-inflammatory markers, stress, and immune genetic background, linking etiology and psychiatry. The third section describes each disorder (ie autism, schizophrenia, bipolar disorder, depression…) with an overview of underlying immune dysfunctions. Lastly, the authors discuss the innovative immune-therapies that may result from the discovery of immune system biomarkers and their associated mechanisms. A better understanding of the role of the immune system in psychiatric disorders makes it possible to identify stratification biomarkers, to explain underlying mechanisms, and to develop innovative, efficient, targeted treatment strategies and management. As such, the book is of value to clinicians, mental health professionals, mental health researchers, immunologists, industry practitioners, and various stakeholders in the mental health field.
Tabla de materias
Foreword.- 1. Auto-immune disorders and infections as risk factors for mental disorders.- 2. The life-long consequences of prenatal and childhood stress on the innate and adaptive immune system.- 3. Immunity as a common risk pathway for psychiatric and medical comorbidity?.- 4. Brain imaging Measures of Immune Dysregulation in Psychiatry.- 5. Cytokines as biomarkers in psychiatric disorders: methodological issues.- 6. Pro-inflammatory cytokines and the depressive phenotype function.- 7. Role of the T Cell Network in Psychiatric Disorders.- 8. Microglia and psychiatric disorders.- 9. Human Endogenous Retrovirus as missing link in the global etiopathogenesis of schizophrenia and bipolar disorder.- 10. The Human Leukocyte Antigen system in Psychiatry: Where do we stand?.- 11. Testable Hypotheses Relating Complement Pathways to Elevated Risk for Schizophrenia.- 12. Gut microbiome in patients with schizophrenia and bipolar disorders.- 13. Is Autism Spectrum Disorder related to immune dysfunction?.- 14. Inflammation and immunity in depression.- 15. The aberrant Immune system and Bipolar disorder.- 16. Immune dysfunction and depression: is Immunometabolism the missing link?.- 17. Immune dysfunction in obsessive-compulsive disorder: from risk factors to multisystem involvement.- 18. Immune dysfunction and catatonia.- 19. Suicide as a Systemic Disorder.- 20. RDo C and inflammation.- 21. The concept of auto-immune psychosis.- 22. Immunotherapy in the treatment of Psychosis.- 23. Immuno-Modulation of Resistant Depression.- 24. Diet, immune system and psychiatric disorders.- 25. Constituents of a Healthy Dietary Pattern.- 26. Exercise and Inflammation.
Sobre el autor
Michael Berk is an NHMRC Senior Principal Research Fellow at Deakin University, where he heads the IMPACT institute. He is listed by Thompson Reuters as amongst the world’s most influential scientific minds (2015-2020) and was awarded the Brain & Behaviour (NARSAD) Colvin Award for Mood Disorders in 2015, the Victoria Prize for life sciences in 2019 and the International Society for Bipolar Disorders Bob Post award for mentorship in 2020. He is past president of the International Society for Bipolar Disorders and the Australasian Society for Bipolar and Depressive Disorders. His major interests are in the discovery and implementation of novel therapies.
Marion Leboyer M.D., Ph.D. is Professor of Psychiatry at the University of Paris Est Créteil (UPEC) in France. She is Head of the University-affiliated Department of Psychiatry and Addiction, DMU IMPACT (Hôpitaux Universitaires Mondor, Assistance-Publique-Hôpitaux de Paris) and runs the “Translational Neuro Psychiatry” laboratory which is part of the Mondor Institute for Biomedical Research (Inserm U955). Since 2007, she has been the Executive Director of the non profit foundation, “Fondation Fonda Mental”, created by the French Ministry of Research. She is President of the ECNP Immuno-psychiatry TWG. She is listed as a highly cited researcher in 2020.
Iris Sommer MD, Ph D is a Professor of Psychiatry working at the Biomedical and Psychiatry Departments of the University Medical Center Groningen (UMCG) in the Netherlands. She is an expert in psychotic disorders and leads several trials aiming to improve treatment in this patient group. She is an associate editor of Lancet Psychiatry and Psychological Medicine, and a board member of ECNP and SIRS. She is a founding member of the International Consortium of Hallucination Research and initiated the Gordon Research Conference cycle on cognitive dysfunction in brain disorders together with Prof. Linda Lam from the Chinese University of Hong Kong. In 2021, she was elected member of the Royal Holland Academy of Science.
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