100 years of Human Chorionic Gonadotropin: Reviews and New Perspectives is a collection of articles written by some of the world’s leading experts on the pregnancy hormone and cancer marker h CG. In 2019 it is difficult to ignore the effect that our understanding of h CG has had on the lives of millions of people worldwide. The h CG immunoassay, in one form or another, is now one of the most common medical tests conducted and is often the first indication that a mother-to-be is pregnant. Not only a marker of pregnancy, h CG is utilized in the diagnosis and monitoring in oncology and presents a potential target for novel cancer therapeutics. 100 years ago, in 1919, Hirose was demonstrating gonadotropic functions which resulted from a chorionic factor. Over the last century this factor has become defined as h CG and more recently explored as not one molecule but a group of molecules with variable structure and variable functions in both pregnancy and cancer. h CG is a multi-faceted molecule that has clinical and therapeutic implications but can be a challenging topic for researchers and physicians alike. This text covers the different structures and functions of h CG exploring the genes and evolution of the molecule, the different protein and glycosylation structures which can exist and their effect on structure, detection and quantification. 100 Years of h CG is not an attempt to recount the history of every publication on h CG, but rather a collection of reviews and new perspectives by "h CG-ologists", the term used by Hussa to describe biochemists working on HCG in the first book written on the topic over 30 years ago. Some of the authors have been around a while, some not so long, but others are just beginning their journey with a most beguiling molecule. – Provides updated information on a complex and changing subject in five sections- Reviews historical perspectives and developments over the last 100 years- Includes novel insights into the structure, function and detection of h CG in pregnancy and cancer- Includes chapters on the use of mass spectrometry to detect and quantify h CG as well as traditional immunoassays and over the counter pregnancy tests- Describes the role of h CG in pregnancy, endometrial receptivity and embryo implantation and the use in fertility treatment- Addresses the specific hyperglycosylated h CG test that can distinguish a normal term from a failing pregnancy and also screen for preeclampsia and gestational hypertension in pregnancy as well as its use as a marker and treatment target in cancer. – Includes chapters on the development and use of h CG vaccines- Includes a section on h CG and in subunits in cancer
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