Irritant dermatitis is a common condition, accounting for a significant proportion of occupational skin disease. The recent advent of non-invasive skin bioengineering technology has accelerated dermatology research in this field. This book comprises an exhaustive reference text on irritant contact dermatitis, covering all aspects of the condition: clinical features, epidemiology, prevention and therapy, prognosis, mechanisms, pathology and regulatory issues. The book also presents novel in vitro and in vivo research techniques and findings. As irritant dermatitis affects multiple specialties, the audience for this book is wide, including clinical and investigative dermatologists, allergists, toxicologists, pharmaceutical scientists, occupational and environmental physicians, public health physicians, cosmetologists and skin bioengineers.
Table des matières
Classification and Clinical Features.- Ten Genotypes of Irritant Contact Dermatitis.- Irritant Contact Dermatitis ersus Allergic Contact Dermatitis.- Special Clinical Forms.- Barrier Function and Perturbation: Relevance for Interdigital Dermatitis.- Friction Melanosis.- Diaper Dermatitis.- Chemical Skin Burns.- Contact Urticaria Syndrome.- Airborne Irritant Dermatitis.- Irritant Dermatitis of the Scalp.- rritant Contact Dermatitis of the Nails.- Epidemiology.- Importance of Irritant Contact Dermatitis in Occupational Skin Disease.- Irritant Contact Dermatitis in the Tropics.- Occupational Irritant Dermatitis.- Occupational Issues of Irritant Contact Dermatitis.- Hairdressing.- Occupational Irritant Dermatitis — Metal Workers.- Health Care Workers.- The Electronics Industry.- Painters, Lacquerers, and Varnishers.- Risk Factors for Irritant Dermatitis.- Age.- Gender.- Ethnicity.- Atopy.- Insights from Bioengineering.- Prediction Bioengineering.- Quantitative Sonography for the Evaluation of Irritant Reactions.- Functional Skin Testing: the SMART Procedures.- Bioengineering Correlates of the Sensitive Skin Syndrome: The Sensory Irritation Component.- Squamometry.- The Irritants: Special Issues.- Corrosive Materials.- Detergents.- Sodium Lauryl Sulfate.- Organic Solvents.- Oils, Cutting Fluids, and Lubricants.- Food.- Dithranol.- Copper.- Fatty Acid Binding Proteins.- Mechanisms of Irritant Dermatitis.- Histopathology of Irritant Contact Dermatitis.- Percutaneous Absorption and Irritant Dermatitis.- Cytokines and Irritant Dermatitis.- Oxidative Stress.- Langerhans Cells and Skin Irritation.- Hydration Injury.- Prevention of Irritant Dermatitis.- Primary Prevention of Irritant Contact Dermatitis.- Protective Gloves.- Anti-Irritants.- Barrier Creams.- Moisturizers.-Moisturizers and Irritant Contact Dermatitis (2).- Effects of CO2 on Barrier Recovery.- Management and Therapy.- Treatment of Irritant Contact Dermatitis.- Topical Corticosteroids in the Treatment of Irritant Dermatitis.- Barrier Creams and Emollients.- Product Testing.- In Vivo Models of Skin Irritation.- In Vitro Methods to Predict Skin Irritation.- Appendices.- Questionnaire Methods for Hand Dermatitis Studies.- Patient Information Sheets.- Selected Sources of Information for Irritant Contact Dermatitis.
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