“Overall, this is an excellent book on an important topic in cancer that medical oncologists, pharmacologists, and nurses, as well as related healthcare professionals, may find very helpful.”
Score: 100, 5 Stars, Doody’s Medical Reviews
Head and Neck Cancers: Evidence-Based Treatment presents a practical, state-of-the-art resource for any clinical oncologist treating or managing patients with head and neck cancers, including oropharyngeal cancer, cancer of the oral cavity, laryngeal cancer, nasopharyngeal cancer, hypopharyngeal cancer, cancer of the sinuses and the skull base, salivary gland cancer, and neck lymphadenopathy.
Section 1 of the book covers the most pertinent details on the epidemiology, biology, diagnosis and staging of the disease including topics such as the genomic landscape of squamous cell carcinoma of the head and neck and novel imaging modalities. Section 2 discusses the evidence-based treatment modalities for conventional and novel chemotherapy regimens, the evidence behind emerging radiation therapy techniques and the minimally invasive surgical advances changing the landscape of care. The chapters in Section 3 are dedicated to site-specific management, including management guidelines, tables with FDA-approved therapies and relevant ongoing clinical trials as well as instructive clinical cases with important discussion on outcomes and follow up care. Finally, Section 4 focuses on recurrent and metastatic disease and Section 5 provides the essentials on supportive care, including managing the elderly, managing patients suffering from dysphagia and oral complications, and must-know details of quality of life assessment and patient-reported outcomes.
Emphasizing the practice-changing techniques and the latest evidence-based treatment advances including targeted therapies, immunotherapy, transoral robotic surgery, and radiation therapy precision, this comprehensive yet accessible textbook is indispensable for any clinical oncologist of each discipline wanting a balanced and evidence-based reference on managing patients with head and neck malignancies.
Key Features:
- Includes didactic clinical cases for each type of head and neck cancer
- Numerous tables highlight FDA approved therapies and ongoing clinical trials
- Provides evidence-based recommendations for treating head and neck cancers at each stage of the disease with conventional and novel treatment strategies
- Covers strategies for managing acute and late complications to treatment
Table des matières
Contents
Contributors
Preface
SECTION I
Epidemiology, Biology, Diagnosis, and Staging
1. Head and Neck Cancer Epidemiology
Angela L. Mazul, Erich M. Sturgis, Andrew F. Olshan, and Jose P. Zevallos
2. Pathology of HNSCC
Michelle D. Williams and Adel K. El-Naggar
3. The Genomic Landscape of HNSCC
Steffen Wagner, Jens P. Klussmann, and Ruud H. Brakenhoff
4. HPV-Related Head and Neck Cancer Biology
Farhoud Faraji and Carole Fakhry
5. Imaging of Head and Neck Cancers
Rathan M. Subramaniam
SECTION II
Established and Emerging Treatment Modalities
6. Advances in Radiation Therapy Techniques for HNSCC: Image-Guided RT Stereotactic, IMRT-VMAT, MRI-Linac and Simulation
Jussi Sillanpaa, C. Jillian Tsai, and Nancy Y. Lee
7. Proton Therapy
Pierre Blanchard, G. Brandon Gunn, and Steven J. Frank
8. Transoral Robotic Surgery: Advances and Applications
Meghan T. Turner, F. Christopher Holsinger, and Robert L. Ferris
9. Induction Chemotherapy: Current and Emerging Role in HNSCC
Glenn J. Hanna and Robert I. Haddad
10. Immunotherapy for HNSCC: Rationale and Clinical Applications
Jennifer Moy, Jennifer M. Johnson, Jessica Moskovitz, Robert L. Ferris, and Athanassios Argiris
11. Targeting the Human Epidermal Receptor Family in HNSCC
Emmanuel Seront, Sandra Schmitz, and Jean-Pascal Machiels
12. Therapies Targeting VEGF/Angiogenesis and Other Novel Targets and Therapies in HNSCC
Sophie Stock-Martineau, Yanqun Dong, Denis Soulières, and Thomas J. Galloway
SECTION III
Site-Specific Management
13. Oropharyngeal Cancer: HPV-Positive Disease
Christien A. Kluwe, Anthony J. Cmelak, and Barbara A. Burtness
14. Non–HPV-Associated Oropharyngeal Cancer
Meghan T. Turner, Anirudh Saraswathula, and F. Christopher Holsinger
15. Oral Cavity Cancer: Surgical Approaches and Postoperative Treatment
Antoine Eskander, Jacques Bernier, Lisa Licitra, Paolo Bossi, and Theodoros N. Teknos
16. Nasopharyngeal Cancer
Wai Tong Ng, Oscar S. H. Chan, Henry C. K. Sze, Ka On Lam, and Anne W. M. Lee
17. Hypopharyngeal Cancer: A Multidisciplinary Approach
Moran Amit, Loren K. Mell, Cristina P. Rodriguez, and Neil D. Gross
18. Laryngeal Cancer: Organ Preservation Strategies
Arlene A. Forastiere, Jae Lee, Steven B. Chinn, Karim Boudadi, Avraham Eisbruch, Randal S. Weber
19. Malignancies of the Paranasal Sinuses and Skull Base
Heather A. Osborn, Jong Chul Park, Nabil F. Saba, Pierre Blanchard, and Derrick T. Lin
20. Evaluation and Treatment of Metastatic Lymphadenopathy From an Unknown Primary
Shirin Attarian, Richard Blake Ross, Shlomo A. Koyfman, and Missak Haigentz, Jr.
21. Salivary Gland Malignancies
Cristina P. Rodriguez, Jessica L. Geiger, Jon Mallen-St. Clair, Patrick K. Ha, Sue S. Yom, Adam S. Garden, and David J. Adelstein
SECTION IV
Recurrent or Metastatic Disease
22. Locally Recurrent HNSCC: Salvage Surgery, Reirradiation
Antoine Eskander, Sharon A. Spencer, Corey J. Langer, Takashi Maruo, Ryuichi Hayashi, Sadamoto Zenda, and James W. Rocco
23. Recurrent or Metastatic HNSCC: Systemic Therapy
Tomohiro Enokida, Susumu Okano, and Makoto Tahara
SECTION V
Supportive Care and Special Patient Groups
24. Oral Complications
Rajesh V. Lalla and Douglas E. Peterson
25. Dysphagia in Patients With Head and Neck Cancer
Katherine A. Hutcheson and Jan S. Lewin
26. Quality of Life Assessment and Patient-Reported Outcomes in Head and Neck Cancer
Minh Tam Truong and Lisa Ann Kachnic
27. Management of Head and Neck Cancers in the Elderly
Jessica L. Geiger and Julie E. Bauman
Index
A propos de l’auteur
David I. Rosenthal, MD, FACR, FASTRO, Professor of Radiation Oncology and Head and Neck Surgery, and Chief of the Head and Neck Radiation Oncology Service, University of Texas MD Anderson Cancer Center, Houston, Texas
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