This book contains contributions from interdisciplinary scientists to collectively address the issue of targeting carbohydrate recognition for the development of novel therapeutic and diagnostic agents. The book covers (1) biological problems involving carbohydrate recognition, (2) structural factors mediating carbohydrate recognition, (3) design and synthesis of lectin mimics that recognize carbohydrate ligands with high specificity and affinity, and (4) modulation of biological and pathological processes through carbohydrate recognition.
Table des matières
Preface vii
Contributors ix
1 Mammalian Glycan Biosynthesis: Building a Template for Biological Recognition 1
M. Adam Meledeo, Venkata D. P. Paruchuri, Jian Du, Zhiyun Wang, and Kevin J. Yarema
2 The Roles of Carbohydrate Binding in Cell Adhesion and Inflammation 33
Ken Kitajima and Chihiro Sato
3 The Role of Carbohydrates in Viral Infections 65
Gillian M. Air
4 The Role of Carbohydrates in Bacterial Infections 93
Roland J. Pieters
5 The Roles of Carbohydrate Binding in Fertilization 107
David J. Miller
6 Carbohydrate Biomarkers 133
Yunfeng Cheng, Nanting Ni, Hanjing Peng, Shan Jin, and Binghe Wang
7 Galectins and Their Role in Various Biological Processes 157
Sarika Saraswati, Ashley Stanley Block, and Alan B. Diekman
8 Glycoimmunology 181
Ani Grigorian, Barbara Newton, and Michael Demetriou
9 Tools For Glycomics: Glycan and Lectin Microarrays 205
Christopher Campbell and Jeff Gildersleeve
10 Combinatorial Biosynthesis of Complex Carbohydrates 229
Hai Yu and Xi Chen
11 Mass Spectrometry in Carbohydrate Sequencing and Binding Analysis 257
Gregory O. Staples and Joseph Zaia
12 Synthetic Lectin Mimics Artificial Carbohydrate Receptors 301
Xiaochuan Yang, Yunfeng (Jerry) Cheng, and Binghe Wang
13 Lectin Binding and Its Structural Basis 329
Annabelle Varrot, Bertrand Blanchard, and Anne Imberty
14 Multivalency in Carbohydrate Binding 349
Mark L. Wolfenden and Mary J. Cloninger
15 Carbohydrate Binding Agents: Potential Therapeutics with Multiple Inhibitory Actions Against Enveloped Viruses 371
K.O. François and J. Balzarini
16 Informatics for Glycobiology and Glycomics 409
Kiyoko F. Aoki-Kinoshita
Index 427
A propos de l’auteur
BINGHE WANG, PHD, is Professor and Chair of the Department of Chemistry at Georgia State University as well as Georgia Research Alliance Eminent Scholar in Drug Discovery. He is Editor-in-Chief of the journal Medicinal Research Reviews, Series Editor for the Wiley Series in Drug Discovery and Development, and editor of Drug Delivery: Principles and Applications and Chemosensors: Principles, Strategies, and Applications (Wiley).
GEERT-JAN BOONS, PHD, is Franklin Professor of Chemistry and Professor in the Complex Carbohydrate Research Center at the University of Georgia. He is on the editorial boards of several journals on carbohydrates, including European Journal of Chemistry and Journal of Carbohydrate Chemistry, and is also coeditor of Carbohydrate-Based Immunotherapies and Vaccines (Wiley).
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