The use of thermodynamics in biological research can be equated to an energy book-keeping system. While the structure and function of a molecule is important, it is equally important to know what drives the energy force. This volume presents sophisticated methods for estimating the thermodynamic parameters of specific protein-protein, protein-DNA and small molecule interactions. – Elucidates the relationships between structure and energetics and their applications to molecular design, aiding researchers in the design of medically important molecules- Provides a "must-have" methods volume that keeps MIE buyers and online subscribers up-to-date with the latest research- Offers step-by-step lab instructions, including necessary equipment, from a global research community