Brings together functional and structural informationrelevant to
the design of drugs targeting zinc enzymes
The second most abundant transition element in living organisms,
zinc spans all areas of metabolism, with zinc-containing proteins
offering both established and potential drug targets. Drug
Design of Zinc-Enzyme Inhibitors brings together functional and
structural information relevant to these zinc-containing targets.
With up-to-date overviews of the latest developments field, this
unique and comprehensive text enables readers to understand zinc
enzymes and evaluate them in a drug design context.
With contributions from the leaders of today’s research, Drug
Design of Zinc-Enzyme Inhibitors covers such key topics as:
* Major drug targets like carbonic anhydrases, matrix
metalloproteinases, bacterial proteases, angiotensin-converting
enzyme, histone deacetylase, and APOBEC3G
* Roles of recently discovered zinc-containing isozymes in cancer,
obesity, epilepsy, pain management, malaria, and other
conditions
* Cross reactivity of zinc-enzyme inhibitors and activators
* The extensive use of X-ray crystallography and QSAR studies for
understanding zinc-containing proteins
* Clinical applications
An essential resource for the discovery and development of new
drug molecules, Drug Design of Zinc-Enzyme Inhibitors gives
researchers, professionals, students, and academics the foundation
to understand and work with zinc enzyme inhibitors and
activators.
A propos de l’auteur
Claudiu T. Supuran is a professor in the Department of
Chemistry at the University of Florence, Italy. His main research
interests include medicinal chemistry, design of enzyme inhibitors
and activators, X-ray crystallography of metallo-enzymes, and metal
complexes with biologically active ligands (metal-based drugs). He
has published more than 400 original research papers in these
fields.
Jean-Yves Winum is an assistant professor in the
Department of Chemistry at the University of Montpellier 2
(Institut des Biomolécules Max Mousseron UMR CNRS 5247),
France. His research interests are focused on organic/medicinal
chemistry of metallo-enzyme inhibitors and activators.
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