This book describes a diverse analysis of the five somatostatin receptors; somatostatin gene regulation; promatostatin processing; mechanisms of signal transduction; and the design and use of somatostatin analogues, including their possible clinical implications. The book will provide a comprehensive summary of the cellular and molecular biology of somatostatin and its recently isolated receptors. The book will review the design and use of specific somatostatin analogues both biochemically to characterize the specific functions of somatostatin and clinically in the treatment of various tumors.
Table des matières
Partial table of contents:
Regulation of Somatostatin Gene Transcription by c AMP (M.
Montminy, et al.).
Processing and Intracellular Targeting of
Prosomatostatin-Derived Peptides: The Role of Mammalian
Endoproteases (Y. Patel & A. Galanopoulou).
Molecular Biology of Somatostatin Receptors (G. Bell, et
al.).
Characterization of Somatostatin Receptor Subtypes (Ch.
Bruns, et al.).
Regulation of Somatostatin Receptor m RNA Expression (M.
Berelowitz, et al.).
Transient Expression of Somatostatin Receptors in the Brain
During Development (P. Leroux, et al.).
Interaction of Somatostatin Receptors with G Proteins and
Cellular Effector Systems (T. Reisine, et al.).
Function and Regulation of Somatostatin Receptor Subtypes (A.
Schonbrunn, et al.).
Appendix.
Indexes.
A propos de l’auteur
Derek J. Chadwick and Gail Cardew are editors for Somatostatin and Its Receptors and other scientific titles.
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