The number of factors implicated in the regulation of cell proliferation and differentiation is already considerable and more are continually being identified. This book concentrates on tumor necrosis factor (cachectin) and lymphotoxin, but includes observations of their interactions with other cytokines, especially the interferons and interleukins. TNF can be either cytostatic or cytotoxic to cultured cell lines, and a variety of mechanisms are proposed, ranging from DNA fragmentation to activation of phospholiopases. TNF is also reported to stimulate the growth of normal fibroblasts in vivo. The in vivo actions of TNF described here include haemorrhagic necrosis of tumors, cachexia, effects on the vasculature, and antiparasitic and antiviral activities. Also presented is some interesting data from the first stages of clinical trials of TNF as an anticancer agent.
Table des matières
Natural Production and Release of Tumour Necrosis Factor (G.
Gifford, D. Flick).
Possible Relationships between in vivo Antitumour
Activity and Toxicity of Tumour Necrosis Factor-a (M. Palladino et
al.).
Human Tumour Necrosis Factors: Structure and Receptor
Interactions (B. Aggarwal et al.).
Cytocidal Activity of Tumour Necrosis Factor: Protection by
Protease Inhibitors (C. Baglioni et al.).
Lymphotoxin: Cloning, Regulation, and Mechanism of Killing (N.
Ruddle et al.).
Physiological Responses to Cachectin (K. Tracey et al.).
Structure-function Relationship of Tumour Necrosis Factor and
Its Mechanism of Action (W. Fiers et al.).
Relationship of Tumour Necrosis Factor and Endotoxin to
Macrophage Cytotoxicity, Haemorrhagic Necrosis and Lethal shock (J.
Rothstein, H. Schreiber).
Antitumour Effects of Necrosis Factor: Cytotoxic or Necrotizing
Activity and Its Mechanism (K. Haranaka et al.).
Effects of Tumour Necrosis Factor on Human Tumour Xenografts in
Nude Mice (F. Balkwill et al.).
Effects of Tumour Necrosis Factor and Related Cytokines on
Vascular Endothelial Cells (J. Pober).
Antiparasitic Effects of Tumour Necrosis Factor in vivo
and in vitro (J. Playfair, J. Taverne).
Clinical Studies with Tumour Necrosis Factor (D. Spriggs et
al.).
Summary (L. Old).
Index of Contributors.
Subject Index.
A propos de l’auteur
The Novartis Foundation is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research.
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