Handbook of Hematologic Malignancies provides a unique, practical, and concise guide focused on the must-know points of diagnosis, prognosis, therapeutic management, and cutting edge clinical trial opportunities for each hematologic malignancy. With an ever-increasing growth of evidence and a significant expansion of available treatment options for patients with hematologic disease, remaining current and up-to-date can be extremely challenging for practicing clinicians. This comprehensive subspecialty handbook is designed and organized for the busy hematologist, hematologic oncologist, hematopathologist, and trainee in mind.
Every chapter is richly illustrated with color figures and flow diagrams, and contains helpful tables on differential diagnosis, prognostic scoring systems and therapeutic options. A concise case-based review for testing pathologic diagnosis and clinical knowledge for each chapter is included for digital download online and in the e-book. Written by experienced clinicians at the world-renowned Moffitt Cancer Center in Tampa, Florida, as well as contributions from leading academicians throughout the country, this handbook is an essential resource for anyone diagnosing, treating, or managing patients with hematologic malignancy.
KEY FEATURES:
- Contains clear prognostic and diagnostic tools (e.g., tables/flow diagrams/pathology images) with emphasis on key differential diagnoses and diagnostic dilemmas
- Easy to use treatment recommendations with bullet point format and key references.
- Discusses the future of patient management based on practice changing clinical trials
- Includes access to digitally downloadable case-based clinical scenarios and questions with high resolution pathology images linked to each individual chapter
Table des matières
Contents
Contributors
Expert Reviewers
Foreword John M. Bennett, MD
Preface
Abbreviations
INTRODUCTION AND OVERVIEW
1. Hematopathology Diagnostic Techniques and Assays
Johnny Nguyen and Ling Zhang
MYELOPROLIFERATIVE NEOPLASMS
2. Polycythemia Vera
Liliana Bustamante and Kenneth Zuckerman
3. Essential Thrombocythemia
Susmitha Apuri and Kenneth Zuckerman
4. Primary Myelofibrosis
Andrew Kuykendall and Kenneth Zuckerman
5. Chronic Myelogenous Leukemia
Chetasi Talati and Javier Pinilla-Ibarz
6. Chronic Neutrophilic Leukemia
Saman Nematollahi, Shweta Jain, and Utkarsh Acharya
7. Systemic Mastocytosis
Andrew Kuykendall and Kenneth Zuckerman
8. PDGFRA/PDGFRB/FGFR1 Myeloid Neoplasms
Joseph Clara and Eric Padron
MYELODYSPLASTIC AND BONE MARROW FAILURE SYNDROMES
9. Myelodysplastic Syndromes
Joanna Grabska, David A. Sallman, and Rami Komrokji
10. Aplastic Anemia
Michael Shafique and Rami Komrokji
11. Paroxysmal Nocturnal Hemoglobinuria
Hilda Ding and Michael Jaglal
MYELODYSPLASTIC/MYELOPROLIFERATIVE NEOPLASMS
12. Myelodysplastic/Myeloproliferative Overlap Syndromes
Jennifer Eatrides and Eric Padron
13. Chronic Myelomonocytic Leukemia
Alexandra Gomez and Justin M. Watts
ACUTE MYELOID LEUKEMIA AND RELATED SYNDROMES
14. Acute Myeloid Leukemia
Varun Dhulipala and Kendra Sweet
15. Secondary AML and AML With Myelodysplasia-Related Changes
Seongseok Yun and Jeffrey Lancet
16. Acute Promyelocytic Leukemia
Leidy L. Isenalumhe and Jeffrey Lancet
17. Blastic Plasmacytoid Dendritic Cell Neoplasm
Justin Taylor, Ateefa Chaudhury, and Andrew A. Lane
ACUTE LYMPHOID LEUKEMIA
18. B-Lymphoblastic Leukemia
Aneesha Hossain and Khaled el-Shami
19. BCR-ABL1+ B-Lymphoblastic Leukemia
Aneesha Hossain and Khaled el-Shami
20. T-Lymphoblastic Lymphoma/Leukemia
Keri Maher and Ravitharan Krishnadasan
ACUTE LEUKEMIA OF AMBIGUOUS LINEAGE
21. Acute Leukemia of Ambiguous Lineage
Keri Maher and Ravitharan Krishnadasan
MATURE T- AND NK-CELL LEUKEMIA
22. T-Cell Prolymphocytic Leukemia
Abhijeet Kumar, Srinath Sundararajan, and Ravitharan Krishnadasan
23. T-Cell Large Granular Lymphocytic Leukemia
Magali Van den Bergh and Lubomir Sokol
24. Aggressive Natural Killer Cell Leukemia
Mintallah Haider and Lubomir Sokol
PLASMA CELL DISORDERS
25. Monoclonal Gammopathy of Unknown Significance, Smoldering Myeloma, and Plasmacytomas
Srinath Sundararajan, Abhijeet Kumar, Amit Agarwal, and Neha Korde
26. Multiple Myeloma
Patrick Griffin and Rachid Baz
27. Waldenström’s Macroglobulinemia
Joanna Grabska and Rachid Baz
28. Immunoglobulin Light Chain Amyloidosis
Taxiarchis Kourelis and Morie A. Gertz
HODGKIN LYMPHOMA
29. Hodgkin Lymphoma
Anju Nair and Micah Burch
NON-HODGKIN LYMPHOMA
30. Non-Hodgkin Lymphoma Classification and Diagnostic Evaluation
Johnny Nguyen and Ling Zhang
MATURE B-CELL LYMPHOMA
VERY AGGRESSIVE
31. Burkitt Lymphoma
Anju Nair and Micah Burch
AGGRESSIVE
32. Diffuse Large B-Cell Lymphoma
Jose Sandoval-Sus and Julio Chavez
33. Double Hit Lymphoma
Nikhil Mukhi and Julio Chavez
34. Mantle Cell Lymphoma
Samantha Shams and Bijal Shah
35. Primary Mediastinal Large B-Cell Lymphoma
Andreas Saltos and Julio Chavez
36. Primary Central Nervous System Lymphoma
Liliana Bustamante and Peter Forsyth
37. HIV-Related Lymphomas
Danny Nguyen, Nishan Tchekmedyian, and Jeremy Abramson
INDOLENT
38. Follicular Lymphoma
Asha Balakrishnan and Celeste Bello
39. Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Ateefa Chaudhury and Javier Pinilla-Ibarz
40. Hairy Cell Leukemia
Justin Taylor and Omar Abdel-Wahab
41. Marginal Zone Lymphoma
Nishan Tchekmedyian, Danny Nguyen, and Celeste Bello
42. Mucosa-Associated Lymphoid Tissue Lymphoma
Ridhi Gupta, Matthew Mastrodomenico, Nishan Tchekmedyian, and Saurabh Chhabra
MATURE T/NK-CELL LYMPHOMA
43. Adult T-Cell Leukemia/Lymphoma
Nikhil Mukhi and Lubomir Sokol
44. Anaplastic Large Cell Lymphoma, ALK Positive
Thomas Enzler and Changchun Deng
45. Extranodal Natural Killer/T-Cell Lymphoma
Joseph Clara and Lubomir Sokol
46. Mycosis Fungoides
Achuta Kumar Guddati and Lubomir Sokol
47. Hepatosplenic T-Cell Lymphoma
Narendranath Epperla, Apoorva Jayarangaiah, and Timothy S. Fenske
HISTIOCYTIC/DENDRITIC CELL NEOPLASMS
48. Histiocytic Sarcoma and Langerhans Cell Histiocytosis
Narendranath Epperla and Ehab Atallah
49. Hemophagocytic Lymphohistiocytosis
Hilda Ding and Lubomir Sokol
BONE MARROW TRANSPLANTATION
50. Autologous Bone Marrow Transplantation
Hemant S. Murthy and Mohamed A. Kharfan-Dabaja
51. Allogeneic Bone Marrow Transplantation
Hemant S. Murthy, Taiga Nishihori, and Mohamed A. Kharfan-Dabaja
EMERGENCIES IN HEMATOLOGY
52. Tumor Lysis Syndrome
Mintallah Haider, Ateefa Chaudhury, and Michael Jaglal
53. Thrombotic Microangiopathy
Ruchika Goel, Aaron Tobian, and Ljiljana V. Vasovic
54. Therapeutic Apheresis Indications
Amanda E. Lo, Ruchika Goel, and Ljiljana V. Vasovic
Appendix: Pathology Supplement
Index
A propos de l’auteur
Alan F. List is CEO, Moffitt Cancer Center and Research Institute; and Professor, Department of Internal Medicine and Oncology, University of South Florida College of Medicine, Tampa, FL.
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