Protein Interactions
A fundamental guide to the burgeoning field of protein interactions
From enzymes to transcription factors to cell membrane receptors, proteins are at the heart of biological cell function. Virtually all cellular processes are governed by their interactions, with one another, with cell bodies, with DNA, or with small molecules. The systematic study of these interactions is called Interactomics, and research within this new field promises to shape the future of molecular cell biology.
Protein Interactions goes beyond any existing guide to protein interactions, presenting the first truly comprehensive overview of the field. Edited by two leading scholars in the field of protein bioinformatics, this book covers all known categories of protein interaction, stable as well as transient, as well as the effect of mutations and post-translational modifications on the interaction behavior.
Protein Interactions readers will also find:
- Introductory chapters on protein structure, conformational dynamics, and protein-protein binding interfaces
- A data-driven approach incorporating machine learning and integrating experimental data into computational models
- An outlook on the current challenges in the field and suggestions for future research
Protein Interactions will serve as a fundamental resource for novice researchers who want a systematic introduction to interactomics, as well as for experienced cell biologists and bioinformaticians who want to gain an edge in this exciting new field.
Table des matières
Proteins: structure and conformational dynamics
Protein binding interfaces
Structures, composition, and modelling of protein complexes
Kinetics and energetics of protein-protein encounter
Markov-state models for protein-protein encounter
Correlated, co-evolving mutations at PP interfaces
Protein-protein-docking
Predicting interacting proteins by deep learning
Interactions of membrane proteins
Mass spectrometry to detect stoichiometries of protein complexes
Data resources on protein interactomics
Data integration to resolve composition of very large protein complexes
Cellular protein complexeomes
Interactions of transcription factors with DNA
Interactions of chromatin remodeling proteins and epigenetic reader/writer proteins with DNA
Interactions of proteins with m RNA
Interactions of proteins with biological membranes
Interactions of proteins with small molecules
Small molecule inhibitors of protein interactions
Binding pockets on protein surfaces
Effects of protein mutations on their interactions
Effects of alternative splicing on protein interactions
Effects of post-translational modifications on protein interactions
Summary and outlook
A propos de l’auteur
Volkhard Helms is Professor for Bioinformatics at Saarland University, Germany. He holds a Ph.D. from EMBL Heidelberg and has authored over 200 scientific publications. In 2000 he was named an EMBO Young Investigator.
Olga Kalinina is Professor for Drug Bioinformatics at the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)/Helmholtz Centre for Infection Research (HZI) and Saarland University, Germany. She holds a Ph.D. from the Engelhardt Institute for Molecular Biology of the Russian Academy of Sciences, and has authored over 50 scientific publications.
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