Paul A. Lapchak & John H. Zhang 
Translational Stroke Research [PDF ebook] 
From Target Selection to Clinical Trials

Vascular Targets For Ischemic Stroke Treatment.- Identifying Vascular Targets to Treat Hemorrhagic Stroke.- Experimental Platforms For Assessing White Matter Pathophysiology In Stroke.- Neuroprotection in Stroke.- Protein Aggregation And Multiple Organelle Damage After Brain Ischemia.- Antioxidants And Stroke. Success And Pitfalls.- Caspase-Independent Stroke Targets.- Hypoxia-Inducible Factor: A New Hope To Counteract Stroke.- Thrombin in Ischemic Stroke Targeting.- Toll-Like Receptor Agonists As Antecedent Therapy For Ischemic Brain Injury:  Advancing Preclinical Studies To The Nonhuman Primate.- Angiogenesis and Arteriogenesis As Stroke Targets.- Hematopoietic Growth Factor Family For Stroke Drug Development.- Soluble Epoxide Hydrolase As A Stroke Target.- Membrane Potential As Stroke Target.- Hypothermia To Identify Therapeutic Targets For Stroke Treatment.- Stroke Preconditioning To Identify Endogenous Protective Or Regenerative Mechanisms.- Micro RNAs in Ischemic Brain: The Fine-tuning Specialists and Novel Therapeutic Targets.- Neuroglobin: A Novel Target For Endogenous Neuroprotection.- Characterization Of Novel Neuroprotective Lipid Analogues For The Treatment Of Stroke.- Na+/H+ Exchangers As Therapeutic Targets For Cerebral Ischemia.- Iron as a therapeutic target in intracerebral hemorrhage: Preclinical testing of deferoxamine.- Overcoming Barriers To Translation From Experimental Stroke Models. Animal Models Of Stroke For Preclinical Drug Development: A Comparative Study Of Flavonols For Cytoprotection.- Clinical Relevance In A Translational Rodent Model Of Acute Ischemic Stroke: Incorporating The Biological Variability Of Spontaneous Recanalization.- A Clinically Relevant Rabbit Embolic Stroke Model For Acute Ischemic Stroke Therapy Development: Mechanisms & Targets.- Animal Models of Intracranial Aneurysm for treatment.- Animal Models of SAH and Their Translation to Clinical SAH.- ADME (Absorption, Distribution, Metabolism, Excretion) – The Real Meaning – Avoiding Disaster and Maintaining Efficacy for Preclinical Candidates.- Cee Tox Analysis to De-risk Drug Development: The Three Antioxidants (NXY-059, RADICUT and STAZN).- Site-Specific, Sustained-Release Drug Delivery for Subarachnoid Hemorrhage.- Therapeutic Potential of Intranasal Delivery of Drugs and Cells for Stroke and other Neurological Diseases.- High-Dose Albumin For Neuroprotection In Acute Ischemic Stroke: From Basic Investigations To Multicenter Clinical Trial.- The Translation Procedure Of Low-Level Laser Therapy In Acute Ischemic Stroke- A Non-Pharmaceutics Noninvasive Method.- Use Of Microbubbles In Acute Stroke.- Combination of High-Intensity Focused Ultrasound and Microbubbles for Stroke Treatment.- Cellular Therapy for Ischemic Stroke.- Clinical Trial Design and Repair-Based Therapies after Stroke.- A Critical Review of Stroke Trial Analytical Methodology: Outcome Measures, Study Design and Correction for Imbalances.- Metabolic Imaging in Translational Stroke Research.- Computational Analysis: A bridge to translational stroke treatment.- Innovations in stroke clinical trial design.