In 2000, the Conference on Automation joined forces with a partner group on situation awareness (SA). The rising complexity of systems demands that one can be aware of a large range of environmental and task-based stimulation in order to match what is done with what has to be done. Thus, SA and automation-based interaction fall naturally together and this conference is the second embodiment of this union. Moving into the 21st century, further diversification of the applications of automation will continue–for example, the revolution in genetic technology. Given the broad nature of this form of human-machine interaction, it is vital to apply past lessons to map a future for the symbiotic relationship between humans and the artifacts they create. It is as part of this ongoing endeavor that the present volume is offered.