The book provides an overview of the development and applications of clinically relevant hydrogels, used particularly in tissue engineering, regenerative medicine, and drug delivery. It approaches the topic from chemistry, materials science, biology, medicine, nanotechnology, and bioengineering points of view. The book first reviews proteins and polysaccharides that mimic extracellular matrix. This is followed by the discussion of generation and applications of supramolecular hydrogels. The final part of the book covers design and functions of cell encapsulation systems.
Table des matières
Preface
Extracellular Matrix Hydrogels from Decellularized Tissues for Biological and Biomedical Applications
Collagen Based Systems to Mimic the Extracellular Environment
Designing Elastin-Like Recombinamers for Therapeutic and Regenerative Purposes
Enzyme-Assisted Hydrogel Formation for Tissue Engineering Applications
Hierarchical Peptide- and Protein-Based Biomaterials: From Molecular Structure to Directed Self-Assembly and Applications
Short Peptide Hydrogels for Biomedical Applications
Supramolecular Assemblies of Glycopeptides as Mimics of the Extracellular Matrix
Supramolecular Assemblies for Cancer Diagnosis and Treatment
Polyzwitterionic Hydrogels as Wound Dressing Materials
Hyaluronan-Based Hydrogels as Modulators of Cellular Behaviour
Hydrogel Fibers Produced via Microfluidics
Embedding Hydrogels into Microfluidic Chips: Vascular Transport Analyses and Drug Delivery Optimization
Multifunctional Granular Hydrogels for Tissue-Specific Repair
Injectable Hydrogels as a Stem Cell Delivery Platform for Wound Healing
Index
A propos de l’auteur
Ricardo A. Pires is a Senior Researcher at 3B’s (Biomaterials, Biodegradables and Biomimetics) Research Group at University of Minho, Guimarães, Portugal, and works part of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine at University of Minho. He did his Ph.D. at Instituto Superior Técnico, University of Lisbon, Portugal in 2004. His research interests include supramolecular hydrogels, protein aggregation, and bionanomaterials.
Iva Pashkuleva is Principal Researcher at 3B’s (Biomaterials, Biodegradables and Biomimetics) Research Group at University of Minho, Guimarães, Portugal. She also works for the European Institute of Excellence on Tissue Engineering and Regenerative Medicine at University of Minho. She received her Ph.D. in Organic Synthesis from University of Sofia, Bulgaria in 2000 and worked there as Assistant Professor until 2002. Her research interests include glycan supramolecular systems, self-assembly, and cell-surface interactions.
Rui L. Reis is Director of 3B’s (Biomaterials, Biodegradables and Biomimetics) Research Group and Professor of Polymer Engineering at University of Minho, Guimarães, Portugal. He is also the CEO of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, the Coordinator of the Discoveries Centre for Regenerative and Precision Medicine, Global President of the Tissue Engineering and Regenerative Medicine International Society (TERMIS) and the Editor-in-chief of the Journal of Tissue Engineering and Regenerative Medicine (Wiley). He received his Ph.D. in Polymer Engineering from University of Minho in co-operation with Brunel University, UK. He has published more than 100 research articles and holds around 60 patents. His research interests include tissue engineering, regenerative medicine, biomaterials, and biodegradable polymers.
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