Ciba Foundation Symposium 123 Antidepressants and Receptor Function
Chairman: Dennis Murphy, 1986
Depression is a common and often debilitating affective disorder. Attempts to develop effective antidepressants have a long history, but many questions remain about the mechanisms of action of such treatments and about the aetiology and pathophysiology of depression itself. Early observations centred attention on central monoamine systems, and animal studies suggested that changes in beta-adrenoceptor responsiveness were a common effect of antidepressant therapies. More recent research has encompassed many different central and peripheral receptors, time-dependent adaptational events at synapses, and the functional significance of changes in neurotransmitter systems in both humans and experimental animals. Such pharmacological studies aimed ultimately at elucidating the neurochemical basis of depression and of promoting new therapeutic approaches, provide the focus of this symposium volume. Many different methods of investigating the links between monoamine systems, depression and antidepressant treatments are described. Recent studies of receptors and of monoamine uptake sites in the brain and the periphery (e.g. in platelets and fibroblasts) are reviewed, with emphasis on alpha and beta adrenoceptors, [³H]imipramine-binding sites and serotonin receptors. The results of monitoring amine metabolites in cerebrospinal fluid and of measuring neuroendocrine, physiological and behavioural responses to pharmacological challenge are presented, providing information on monoaminergic function in depressed patients and experimental animals before, during and after treatment with antidepressant drugs or electroconvulsive shock. Genetic influences on receptor density are also discussed, as is the relevance to human depressive illness of animal models, including stress-induced behavioural depression in rats and responses to social stressors in rhesus monkeys.
This book should be of interest to neuropharmacologists, psychopharmacologists, clinical pharmacologists, behavioural scientists, psychiatrists and neuroscientists.
Table des matières
Symposium on Depression, antidepressants and receptor sensitivity,
held at the Ciba Foundation, London, 19-21 November 1985
Editors: Ruth Porter, Gregory Bock (Organizer) and Sarah
Clark
D. Murphy Introduction
S.Z. Langer, A.M. Galzin, C.R. Lee and H. Schoemaker
Antidepressant-binding sites in brain and platelets
Discussion
W.H. Berrettini, J. Bardakjian, A.L. Barnett Jr, J.I. Nurnberger
Jr and E.S. Gershon beta-Adrenoceptor function in human adult
skin fibroblasts: a study of manic-depressive illness
Discussion
P. Propping, W. Friedl, J. Hebebrand and K-U. Lentes Genetic
studies at the receptor level: investigations in human twins and
experimental animals
Discussion
M. Åsberg and A. Wägner Biochemical effects of
antidepressant treatment–studies of monoamine metabolites in
cerebrospinal fluid and platelet [³H]imipramine
binding
Discussion
R.W. Horton, C.L.E. Katona, A.E. Theodorou, A.S. Hale, S.L.
Davies, C. Tunnicliffe, Y. Yamaguchi, E.S. Paykel and J.S. Kelly
Platelet radioligand binding and neuroendocrine challenge tests in
depression
Discussion
D.L. Murphy, C.S. Aulakh and N. A. Garrick How antidepressants
work: cautionary conclusions based on clinical and laboratory
studies of the longer-term consequences of monoamine
oxidase-inhibiting antidepressants
Discussion
S.A. Checkley, T.H. Corn, I.B. Glass, C. Thompson, C. Franey and
J. Arendt Neuroendocrine and other studies of the mechanism of
antidepressant action of desipramine
Discussion
L.J. Siever, E.F. Coccaro, E. Benjamin, K. Rubinstein and K.L.
Davis Adrenergic and serotonergic receptor responsiveness in
depression
Discussion
General discussion I
A. Frazer, G. Ordway, J. O’Donnell, P. Vos and B. Wolfe
Effect of repeated administration of clenbuterol on the regulation
of beta-adrenoceptors in the central nervous system of the
rat
Discussion
J.M. Weiss and P.G. Simson Depression in an animal model: focus
on the locus ceruleus
Discussion
G.W. Kraemer Causes of changes in brain noradrenaline systems
and later effects on responses to social stressors in rhesus
monkeys: the cascade hypothesis
Discussion
J. Vetulani, L. Antkiewicz-Michaluk, A. Rokosz-Pelc and J.
Michaluk Effects of chronically administered antidepressants and
electroconvulsive treatment on cerebral neurotransmitter receptors
in rodents with ‘model depression’
Discussion
A.R. Green, D.J. Heal and G.M. Goodwin The effects of
electroconvulsive therapy and antidepressant drugs on monoamine
receptors in rodent brain–similarities and differences
Discussion
General discussion II
Closing remarks
Index of contributors
Subject index
A propos de l’auteur
The Novartis Foundation is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research.
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