This book constitutes the refereed proceedings of the 18th EAI International Conference, Secure Comm 2022, Virtual Event, October 2022, Proceedings. The 43 full papers included in this book were carefully reviewed and selected from 130 submissions. They were organized in topical sections as follows: AI for Security, Applied Cryptography, Binary Analysis, Blockchain, Cryptography, Data Security, Intrusion Detection, Mobile Security, Network Security, Privacy, Software Security, Security and Privacy-preserving Solutions in the Internet of Things (S/P-Io T).