* Most current state-of-the-art overview of this important class
of compounds, encompassing many new and emerging
applications
* The number of articles on organic azides continues to increase
tremendously; on average, there are more than 1000 new publications
a year
* Covers basic chemistry as well as state-of-the-art applications
in life science and materials science
* World-ranked authors describe their own research in the wider
context of azide chemistry
* Includes a chapter on safe synthesis and handling (azides can
decompose explosively)
Table des matières
Forewords: Rolf Huisgen, Valery Fokin, and Barry Sharpless.
Preface.
List of Contributors.
Abbreviations.
PART 1: SYNTHESIS AND SAFETY.
1 Lab-Scale Synthesis of Azido Compounds: Safety Measures and
Analysis (Thomas Keicher and Stefan Löbbecke).
2 Large-Scale Preparation and Usage of Azides (Jürgen
Haase).
3 Synthesis of Azides (Teresa M.V.D. Pinho e Melo).
4 Azides by Olefin Hydroazidation Reactions (Jérôme
Waser and Erick M. Carreira).
PART 2: REACTIONS.
5 The Chemistry of Vinyl, Allenyl, and Ethynyl Azides (Klaus
Banert).
6 Small Rings by Azide Chemistry (Thomas L. Gilchrist and Maria
José Alves).
7 Schmidt Rearrangement Reactions with Alkyl Azides (Scott
Grecian and Jeffrey Aubé).
8 Radical Chemistry with Azides (Ciril Jimeno and Philippe
Renaud).
9 Cycloaddition Reactions with Azides: An Overview (Christine
Schilling, Nicole Jung and Stefan Bräse).
10 Dipolar Cycloaddition Reactions in Peptide Chemistry
(Christian Wenzel Tornøe and Morten Meldal).
11 Photochemistry of Azides: The Azide/Nitrene Interface (Nina
Gritsan and Matthew Platz).
12 Organoazides and Transition Metals (Werner R. Thiel).
PART 3: MATERIAL SCIENCES.
13 Azide-containing High Energy Materials (Thomas M.
Klapötke and Burkhard Krumm).
14 Azide Chemistry in Rotaxane and Catenane Synthesis
(Stéphanie Durot, Julien Frey, Jean-Pierre Sauvage and
Christian Tock).
PART 4: APPLICATION IN BIOORGANIC CHEMISTRY.
15 Aza-Wittig Reaction in Natural Product Syntheses (Francisco
Palacios, Concepción Alonso, Domitila Aparicio, Gloria
Rubiales and Jesús M. de los Santos).
16 Azides in Carbohydrate Chemistry (Henning S.G. Beckmann and
Valentin Wittmann).
Index.
A propos de l’auteur
Stefan Bräse was born in Kiel, Germany, in 1967 and
studied chemistry in Göttingen, Bangor (UK) and Marseille
(France). In 1995, he obtained his doctorate after working with
Armin de Meijere at the University of Göttingen. After
post-doctoral appointments at Uppsala University, Sweden (J.-E.
Bäckvall) and The Scripps Research Institute, La Jolla, USA
(K. C. Nicolaou), he began his independent research career at the
RWTH Aachen associated with Dieter Enders in1997 and finished his
habilitation in 2001. He became Professor at the University of Bonn
that same year. Since 2003, he is Full Professor at the University
of Karlsruhe – in October 2009 renamed to the Karlsruhe
Institute of Technology. Stefan Bräse has published more than
100 publications and is recipient of the ORCHEM award in 2000. His
research interests include methods in drug-discovery (including
drug delivery), combinatorial chemistry towards the synthesis of
biologically active compounds, total synthesis of natural products
and nanotechnology.
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