The fine balance in reactive species (RS) levels inside the cell, or redox homeostasis, is crucial for normal life. RS are molecules such as hydroxyl, superoxide, and others whose reaction rates are typically high. Further, RS are now accepted as the molecular mediators of stresses on cells. RS are also implicated in many diseases including cancer, cardiovascular diseases, and neurodegenerative diseases.

In contrast to the popular view that RS are deleterious, this book discusses desirable outcomes from the manipulation of reactive species levels in the cells. The discoveries include a fundamental approach to overcome major limitations with traditional oxygen supply to bioreactors, a mere treatment of the inoculum to significantly (sometimes many-fold) increase productivity of bio-oil, enzymes, and other products from bioprocesses, unexpected effect of shear on cultivated cells, rhythms in intracellular reactive species levels and resetting the rhythm to significantly improve cancer drug efficiency.

The book concludes with a description of a scalable reactive species module — one that can be integrated with any genome scale model to gain significant insights into the RS effects on metabolism.

Contents:

• Relevance and Importance of Reactive Species


• Analysis of Reactions that Involve Reactive Species


• Measurement of Reactive Species Levels in Biological Systems


• Reactive Species in Cell Signaling


• Reactive Species in Oxygen Supply


• Inoculum RS Induction to Improve Bioreactor Productivities


• Reactive Species and Other Stresses


• Reactive Species Aspects in Nano-bio-systems


• Reactive Species in Cancer Treatment and Management


• A Reactive Species Module for Integration into Metabolic Networks

Readership: Graduate students, advanced undergraduate students, researchers and practitioners in the field on biological engineering, bioprocesses, stress-related improvements, and related aspects.

Key Features:

• It is a unique book in the area of reactive species (RS) manipulations in biological systems


• It can be used to teach a relevant course in RS as well as to know the interesting engineering possibilities with RS


• Based on three decades of research in the area of RS applications