Users play a key role in many training strategies, yet many organizations, which are directly or indirectly involved in training those who design and implement training programs, often fail to understand the users’ perception after a simulation training implementation. In addition, there exists a lack of significant motivation to understand users’ attitudes about acceptance, rejection, or integration of emerging simulation technology in training. Several factors are considered to contribute to the acceptance level of simulation training by the users, including cost, the existing training, certification policies, technical issue, and realism of training. Other contributing factors that shape users’ attitudes about the use of simulators in training include, but are not limited to: values, concerns, effectiveness to teach the required skill, and the effect on the training outcome.In this research-based book, the author shares and discusses the lived experiences of medical simulation training users in decision making and non-decision making roles who had been involved in simulation training at least for one year. In addition, this book contains information about concepts of simulation training, a historical perspective of simulation technology across industries, and simulation training users’ perceptions, their lived experiences, feelings associated with the experience, and interactions. The book discusses how those feelings, perceptions, opinions, attitudes, and interactions have evolved. The users’ perception, beliefs, and feelings all affect their interpersonal dynamics, interactions, and communications during the adoption and implementation of simulation technology. Understanding medical simulation training through the users’ perspectives can redefine how trainees communicate, interact, share, and learn in simulated environments. The identified factors discussed by users in this book help with the subsequent additions and modifications to the existing simulation training strategies in the medical field, which may be applicable to other industries. Simulation training supplements passive learning environments, which enables trainees to practice knowledge, skills, abilities, and attitudes acquired in a passive training environment, and empowers trainees to use their learned skills in real world situations.