This continuing series gathers and presents original research results on the leading edge of medicine and biology. Each article has been carefully selected in an attempt to present substantial topical data across a broad spectrum. Topics discussed include the biology and prevalence of A. caninum parasites; the hyalectan class of proteoglycans and their binding partners during vertebrate development; the onset of the hypothalamic-hyptophpyseal-gonadal function during puberty; periodontal disease relating to systemic disease; peripheral arterial fractility from hemodynamic data; medical simulation training; carrier rates of pathogenic bacteria; glycosaminoglycan glycotechnology; and emergency medicine issues.