This volume constitutes the proceedings of the 11th International Work-Conference on IWBBIO 2023, held in Meloneras, Gran Canaria, Spain, during July 15-17, 2022.The 54 full papers were carefully reviewed and selected from 148 submissions. They were organized in the following topical sections: Healthcare and Diseases, Machine Learning in Bioinformatics, New Advances in Deep Learning in Bioinformatics and Biomedicine, Novel Methodologies and Applications in Bioinformatics and Biomedicine.
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