This book brings together the closely observed development of Simone (from birth to three) and the perceptive comments of Martha (or Mattie) Harris, who was such an influential figure in the development of the Observational Studies Course at the Tavistock. Romana Negri’s pioneering work on neonatal intensive care units is informed both by infant observation and by psychoanalysis. She presents in this volume the transcribed tapes of her detailed observation of a normally developing infant, whom Martha Harris supervised for three years. Other chapters present observations of children in hospital that formed part of their diagnostic assessment, and the book includes commentaries by Donald Meltzer and Martha Harris together. This book will be of outstanding interest to all readers whether parents, teachers, or mental health professionals who wish to deepen their understanding of the roots of mental life.