The realisation that human, animal, viral and bacterial genomes all contain over-representation of higher-order quadruplex structures in regulatory and other pharmacologically-useful regions, has led to a large number of studies aimed at exploiting this findings for therapeutic and diagnostic purposes. Quadruplex-binding small molecules are starting to be evaluated in human clinical trials. – Provides the authority and expertise of leading contributors from an international board of authors- Presents the latest release in the Annual Reports in Medicinal Chemistry series
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