This book describes primary results on the leading edge of in silico and in vitro cancer research and summarizes the anticancer activity of pharmacologically important flavonols such as quercetin, morin, kaempferol, fisetin, galangin, diosmetin, and cianidanol. Natural products are a prime source of lead compounds suitable for further modification during drug development. Cancer drug discovery is a risky, costly, and resource-consuming process. In the modern arena, molecular computer modeling in anticancer drug development is utilized to speed up hit identification and optimization of the pharmacological profile. The first chapter of this book deals with computer-aided drug discovery and anticancer drug design using pharmacological active flavonols. In further chapters, the authors discuss the in vitro and in vivo advancement in anticancer research on important flavonols such as quercetin, morin, kaempferol, fisetin, galangin, diosmetin, and cianidanol. Anticancer advancement research related to various cancers is summarized and discussed, giving special emphasis on the effect on apoptosis, migrations, and growth via various signaling pathways. The book encompasses the literature as well as target identification for the selected flavonols for their in silico anticancer potential. Moreover, it also contains experimentation results and discussion on the pharmacological properties, including ADME/T, of the flavonols. Overall, this book can lay a good basis for the subsequent rise for its application as a therapeutic drug in the near future.
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भाषा अंग्रेज़ी ● स्वरूप PDF ● पेज 159 ● ISBN 9781536196092 ● संपादक Shashank Kumar ● प्रकाशक Nova Science Publishers, Inc. ● प्रकाशित 2021 ● डाउनलोड करने योग्य 3 बार ● मुद्रा EUR ● आईडी 8062672 ● कॉपी सुरक्षा Adobe DRM
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