* This book is a comprehensive and up-to-date account of where we
stand in immunological strategies for preventing or treating type 1
diabetes (T1D).
* Brings together contributions from the leaders in the arena of
clinical immunotherapy, not limited to the diabetes field
exclusively, in order to delineate a road-map that would lead to
future clinical trials.
* The book integrates information from human and animal
studies.
* The book considers T1D within the broader context of autoimmune
disease.
* The format contains several discussions, which address specific
questions and provides guidelines for future strategies and
solutions for discovering a cure.
Daftar Isi
1. Michael Rutter
Introduction: whither gene-environment interactions?
2. Rudolf Uher
Gene-environment interaction: overcoming methodological
challenges
Discussion
3. Marco Battaglia, Cecilia Marino, Michel Maziade, Massimo
Molteni and Francesca D’Amato
Gene-environment interaction and behavioural disorders: a
developmental perspective based on endophenotypes
Discussion
4. Naomi R. Wray, William L. Coventry, Michael R. James,
Grant W. Montgomery, Lindon J. Eaves and Nicholas G.
Martin
Use of monozygotic twins to investigate the relationship between
5HTTLPR genotype, depression and stressful life events: an
application of Item Response Theory
Discussion
Appendix
General discussion I
5. Harold Snieder, Xiaoling Wang, Vasiliki Lagou, Brenda W.
J. H. Penninx, Harriëtte Riese and Catharina A.
Hartman
Role of gene-stress interactions in gene-finding
studies
Discussion
6. Kenneth A. Dodge
Practice and public policy in the era of gene-environment
interactions
Discussion
7. Kristi B. Adamo and Frédérique
Tesson
Gene-environment interaction and the metabolic
syndrome
Discussion
General discussion II
8. Stephen P. Robertson and Richie
Poulton
Longitudinal studies of gene-environment interaction in
common diseases–good value for money?
Discussion
9. Kee-Seng Chia
Gene-environment interactions in breast cancer
Discussion
10. Malak Kotb, Nourtan Abdeltawab, Ramy Aziz,
Sarah Rowe, Robert W. Williams and Lu Lu
Unbiased forward genetics and systems biology approaches to
understanding how gene-environment interactions work to
predict susceptibility and outcomes of infections
Discussion
11. Steven R. Kleeberger and Hye-Youn
Cho
Gene-environment interactions in environmental lung
diseases
Discussion
General discussion III
12. Fernando D. Martinez
Gene-environment interaction in complex diseases: asthma
as an illustrative case
Discussion
13. Michael Rutter
Conclusions: taking stock and looking ahead
Glossary
Index of contributors
Subject index
Tentang Penulis
The Novartis Foundation is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research.
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